Mkks - McKusick-Kaufman syndrome Gene

Mus musculus

Also known as Bbs6; 1300013E18Rik

Gene ID: 59030 | Gene type: protein coding

About Mkks

Summary

This gene encodes a protein which shares sequence similarity with Other members of the type II chaperonin family. The encoded protein is a centrosome-shuttling protein and plays an important role in cytokinesis. This protein also interacts with Other type II chaperonin members to form a complex known as the BBSome, which involves ciliary membrane biogenesis. This protein is encoded by a downstream open reading frame (dORF). Several upstream open reading frames (uORFs) have been identified, which repress the translation of the dORF, and two of which can encode small mitochondrial membrane proteins. Alternatively spliced transcripts encoding distinct isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Mkks Products(4)

mRNA	Protein	Name
NM_001141946.1	NP_001135418.1	molecular chaperone MKKS isoform 1
NM_001286981.1	NP_001273910.1	molecular chaperone MKKS isoform 2
NM_001286983.1	NP_001273912.1	molecular chaperone MKKS isoform 3
NM_021527.2	NP_067502.2	molecular chaperone MKKS isoform 1

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within artery smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	20852044	MGI
acts upstream of or within brain morphogenesis	IMP IMP: Inferred from mutant phenotype	18032602	MGI
acts upstream of or within cartilage development	IMP IMP: Inferred from mutant phenotype	19195025	MGI
acts upstream of or within cerebral cortex development	IMP IMP: Inferred from mutant phenotype	18032602	MGI
acts upstream of or within chaperone-mediated protein complex assembly	IMP IMP: Inferred from mutant phenotype	20080638	MGI
acts upstream of or within cilium assembly	IMP IMP: Inferred from mutant phenotype	15772095	MGI
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	18299575	MGI
acts upstream of or within detection of mechanical stimulus involved in sensory perception of sound	IMP IMP: Inferred from mutant phenotype	16170314	MGI
acts upstream of or within face development	IMP IMP: Inferred from mutant phenotype	18443298	MGI
involved in fat cell differentiation	IEP IEP: Inferred from expression pattern	17379567	MGI
acts upstream of gene expression	IMP IMP: Inferred from mutant phenotype	18317593	MGI
acts upstream of or within hippocampus development	IMP IMP: Inferred from mutant phenotype	18032602	MGI
acts upstream of or within leptin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	19150989	MGI
acts upstream of or within negative regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	23716571	MGI
acts upstream of or within negative regulation of actin filament polymerization	IMP IMP: Inferred from mutant phenotype	23716571	MGI
involved in negative regulation of appetite by leptin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	19150989	MGI
acts upstream of or within negative regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	18317593	MGI
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18317593	MGI
acts upstream of or within non-motile cilium assembly	IGI IGI: Inferred from genetic interaction	16170314	MGI
acts upstream of or within non-motile cilium assembly	IMP IMP: Inferred from mutant phenotype	16170314	MGI
acts upstream of or within photoreceptor cell maintenance	IMP IMP: Inferred from mutant phenotype	15772095	MGI
acts upstream of or within positive regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	18317593	MGI
involved in regulation of cilium beat frequency involved in ciliary motility	IMP IMP: Inferred from mutant phenotype	18299575	MGI
acts upstream of or within regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	23716571	MGI
acts upstream of or within response to inositol	IDA IDA: Inferred from direct assay	34093381	MGI
acts upstream of or within response to leptin	IMP IMP: Inferred from mutant phenotype	18317593	MGI
acts upstream of or within sensory perception of smell	IMP IMP: Inferred from mutant phenotype	15772095	MGI
acts upstream of or within social behavior	IMP IMP: Inferred from mutant phenotype	15772095	MGI
acts upstream of or within spermatid development	IMP IMP: Inferred from mutant phenotype	15772095	MGI
acts upstream of or within striatum development	IMP IMP: Inferred from mutant phenotype	18032602	MGI
acts upstream of or within vasodilation	IMP IMP: Inferred from mutant phenotype	20852044	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in ciliary basal body	IDA IDA: Inferred from direct assay	22446187	MGI
located in kinociliary basal body	IDA IDA: Inferred from direct assay	22446187	MGI
located in motile cilium	IMP IMP: Inferred from mutant phenotype	18299575	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

molecular chaperone MKKS

McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin

McKusick-Kaufman syndrome protein	McKusick-Kaufman syndrome protein
MKKS protein	mcKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin
protein Bbs6 homolog

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1451A	Imidapril	Inhibitor	99.0%	Yes
HY-B1451	Imidapril hydrochloride	Inhibitor	99.91%	Yes

Pre-clinical Phase

Bioactive Molecules (27)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10542	GW 5074		99.54%	Unkown
HY-152860	Darizmetinib		99.94%	Unkown
HY-152185	BSJ-04-122		99.88%	Unkown
HY-13866	Ro 31-8220 mesylate		99.57%	Unkown
HY-119917	Gossypetin	Inhibitor	99.82%	Unkown
HY-124953	7,3',4'-Trihydroxyisoflavone		99.83%	Unkown
HY-19345A	Vacquinol-1 dihydrochloride	Activator	99.70%	Unkown
HY-100538	DTP3	Inhibitor	98.45%	Unkown
HY-122872	MKK7-COV-9	Inhibitor	97.34%	Unkown
HY-150612	(R)-STU104	Inhibitor	99.91%	Unkown
HY-100538A	DTP3 TFA	Inhibitor	98.20%	Unkown
HY-179044	MKK7-JNK activator 1		/	Unkown
HY-N6579	Arvenin I		89.41%	Unkown
HY-121683	(E)-2-Hexadecenal		99.9%	Unkown
HY-150612S	(R)-STU104-d6		99.90%	Unkown
HY-N0811	Anemarsaponin B	Inhibitor	99.43%	Unkown
HY-13866A	Ro 31-8220		/	Unkown
HY-14411	JNK-1-IN-1	Inhibitor	/	Unkown
HY-177802	C3 sodium	Inhibitor	/	Unkown
HY-181812	JNK2/MKK7 PPI-IN-1	Inhibitor	/	Unkown
HY-19345	Vacquinol-1		99.33%	Unkown
HY-E70759	MKK6 SDTD Recombinant Human Active Protein Kinase		/	Unkown
HY-N11723	Catenarin	Inhibitor	/	Unkown
HY-P10852	TAT-MKK3b	Inhibitor	/	Unkown
HY-RS08471	MKKS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-176228	WEIZ-WX-04-008	Inhibitor	/	Unkown
HY-B1451S	Imidapril-d3 hydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mkks	NCBI	NCBI:8195

Name
Email *

	Sorry, but the email address you supplied was invalid.