EXO5 - exonuclease 5 Gene

Homo sapiens

Also known as DEM1; Exo V; hExo5; C1orf176

Gene ID: 64789 | Gene type: protein coding

About EXO5

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:40,508,767-40,516,038 (from NCBI)

This gene has 11 transcripts (splice variants) and 117 orthologues. Ubiquitous expression in lymph node (RPKM 2.5), appendix (RPKM 2.1) and 25 other tissues.

Summary

The protein encoded by this gene is a single-stranded DNA (ssDNA)-specific exonuclease that can slide along the DNA before cutting it. However, human replication protein A binds ssDNA and restricts sliding of the encoded protein, providing a 5'-directionality to the Enzyme. This protein localizes to nuclear repair loci after DNA damage. [provided by RefSeq, Nov 2016]

EXO5 Products(12)

mRNA	Protein	Name
NM_001346946.2	NP_001333875.1	exonuclease V
NM_001346947.2	NP_001333876.1	exonuclease V
NM_001346948.2	NP_001333877.1	exonuclease V
NM_001346949.2	NP_001333878.1	exonuclease V
NM_001346950.2	NP_001333879.1	exonuclease V
NM_001346951.2	NP_001333880.1	exonuclease V
NM_001346952.2	NP_001333881.1	exonuclease V
NM_001346953.2	NP_001333882.1	exonuclease V
NM_001346954.2	NP_001333883.1	exonuclease V
NM_001346955.2	NP_001333884.1	exonuclease V
NM_001346956.2	NP_001333885.1	exonuclease V
NM_022774.3	NP_073611.1	exonuclease V

EXO5 Protein Structure

Exo5

0
100
200
300
373 a.a.

Protein Preferred Names

Protein Names

exonuclease V

defects in morphology 1 homolog

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04586	EXO5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	EXO5	VGNC	VGNC:40512
Macaca mulatta	EXO5	VGNC	VGNC:72361
Mus musculus	EXO5	MGD	MGI:1920422
Rattus norvegicus	EXO5	RGD	RGD:1309802
Felis catus	EXO5	VGNC	VGNC:61997
Bos taurus	EXO5	VGNC	VGNC:59180