EXO5 - exonuclease 5 Gene

Also Known as DEM1; Exo V; hExo5; C1orf176

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64789

About EXO5

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:40,508,767-40,516,038 (from NCBI)

This gene has 11 transcripts (splice variants) and 117 orthologues. Ubiquitous expression in lymph node (RPKM 2.5), appendix (RPKM 2.1) and 25 other tissues.

Summary

The protein encoded by this gene is a single-stranded DNA (ssDNA)-specific exonuclease that can slide along the DNA before cutting it. However, human replication protein A binds ssDNA and restricts sliding of the encoded protein, providing a 5'-directionality to the enzyme. This protein localizes to nuclear repair loci after DNA damage. [provided by RefSeq, Nov 2016]

EXO5 Products (12)

mRNA Protein Name
NM_001346946.2 NP_001333875.1 exonuclease V
NM_001346947.2 NP_001333876.1 exonuclease V
NM_001346948.2 NP_001333877.1 exonuclease V
NM_001346949.2 NP_001333878.1 exonuclease V
NM_001346950.2 NP_001333879.1 exonuclease V
NM_001346951.2 NP_001333880.1 exonuclease V
NM_001346952.2 NP_001333881.1 exonuclease V
NM_001346953.2 NP_001333882.1 exonuclease V
NM_001346954.2 NP_001333883.1 exonuclease V
NM_001346955.2 NP_001333884.1 exonuclease V
NM_001346956.2 NP_001333885.1 exonuclease V
NM_022774.3 NP_073611.1 exonuclease V

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 4 iron, 4 sulfur cluster binding IDA
IDA: Inferred from direct assay
23095756 GOA
enables single-stranded DNA 5'-3' DNA exonuclease activity IDA
IDA: Inferred from direct assay
23095756 GOA
Biological Process GO Annotation Evidence References Source
involved in interstrand cross-link repair IMP
IMP: Inferred from mutant phenotype
23095756 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
23095756 GOA
located in nucleus IDA
IDA: Inferred from direct assay
23095756 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EXO5 Protein Structure

Exo5

Exo5: Exonuclease V - a 5' deoxyribonuclease (71 - 355)

  • 0
  • 100
  • 200
  • 300
  • 373 a.a.
Protein Preferred Names Protein Names

exonuclease V

  • defects in morphology 1 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04586 EXO5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris EXO5 VGNC VGNC:40512
Macaca mulatta EXO5 VGNC VGNC:72361
Mus musculus EXO5 MGD MGI:1920422
Rattus norvegicus EXO5 RGD RGD:1309802
Felis catus EXO5 VGNC VGNC:61997
Bos taurus EXO5 VGNC VGNC:59180
Others EXO5 NCBI