Myo3a - myosin IIIA Gene

Also Known as 9030416P08Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 667663

Summary

Enables actin filament binding activity; microfilament motor activity; and protein serine/threonine kinase activity. Involved in auditory receptor cell stereocilium organization; cochlea morphogenesis; and sensory perception of sound. Acts upstream of or within several processes, including positive regulation of filopodium assembly; protein phosphorylation; and regulation of actin filament length. Located in filopodium tip; photoreceptor inner segment; and stereocilium tip. Is expressed in cochlea and metanephros. Used to study autosomal recessive nonsyndromic deafness 30. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 30. Orthologous to human MYO3A (Myosin IIIA). [provided by Alliance of Genome Resources, Apr 2022]

Myo3a Products (1)

mRNA	Protein	Name
NM_148413.3	NP_680779.3	myosin-IIIa

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables actin filament binding	IDA IDA: Inferred from direct assay	22264607	MGI
enables microfilament motor activity	IDA IDA: Inferred from direct assay	22264607	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	26754646	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	21895655	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in auditory receptor cell stereocilium organization	IGI IGI: Inferred from genetic interaction	26754646	MGI
involved in auditory receptor cell stereocilium organization	IMP IMP: Inferred from mutant phenotype	26754646	MGI
involved in cochlea morphogenesis	IMP IMP: Inferred from mutant phenotype	26754646	MGI
acts upstream of or within inner ear development	IMP IMP: Inferred from mutant phenotype	21165622	MGI
acts upstream of or within peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	21895655	MGI
acts upstream of or within peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	21895655	MGI
acts upstream of or within positive regulation of filopodium assembly	IGI IGI: Inferred from genetic interaction	22264607	MGI
acts upstream of or within protein autophosphorylation	IDA IDA: Inferred from direct assay	21895655	MGI
involved in regulation of actin filament length	IGI IGI: Inferred from genetic interaction	26754646	MGI
involved in regulation of actin filament length	IMP IMP: Inferred from mutant phenotype	26754646	MGI
involved in sensory perception of sound	IGI IGI: Inferred from genetic interaction	26754646	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	21165622	MGI
involved in sensory perception of sound	IMP IMP: Inferred from mutant phenotype	26754646	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in filopodium tip	IDA IDA: Inferred from direct assay	22264607	MGI
located in photoreceptor inner segment	IDA IDA: Inferred from direct assay	19332056	MGI
is active in stereocilium tip	EXP EXP: Inferred from Experiment	26754646	MGI
located in stereocilium tip	IDA IDA: Inferred from direct assay	21165622	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
myosin-IIIa

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08944	MYO3A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22663	Myo3a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29177	Myo3a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Myo3a	NCBI	NCBI:53904