2. Gene
  3. Rps6ka6 - ribosomal protein S6 kinase polypeptide 6 Gene

Rps6ka6 - ribosomal protein S6 kinase polypeptide 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as RSK4; S6K-alpha-6; 2610524K04Rik

Gene ID: 67071 | Gene type: protein coding

About Rps6ka6

Chromosome X: 110,297,889-110,447,656 reverse strand.GRCm39:CM001013.3

This gene has 11 transcripts (splice variants), 207 orthologues, 7 paralogues and is associated with 9 phenotypes. Biased expression in placenta adult (RPKM 15.3), CNS E11.5 (RPKM 4.6) and 7 other tissues.

Summary

Predicted to enable ribosomal protein S6 kinase activity. Involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of embryonic development; and negative regulation of mesoderm development. Predicted to be located in fibrillar center and mitochondrion. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in several structures, including genitourinary system; nervous system; nose; respiratory system; and thymus primordium. Orthologous to human RPS6KA6 (ribosomal protein S6 kinase A6). [provided by Alliance of Genome Resources, Apr 2022]

Rps6ka6 Products(3)

mRNA Protein Name
NM_001398774.1 NP_001385703.1 ribosomal protein S6 kinase alpha-6 isoform 2
NM_001374707.3 NP_001361636.2 ribosomal protein S6 kinase alpha-6 isoform 2
NM_025949.3 NP_080225.2 ribosomal protein S6 kinase alpha-6 isoform 1

Rps6ka6 Protein Structure

STKc_RSK_N

STKc_RSK_N: cd05582 (192 - 506)

STKc_RSK_C

STKc_RSK_C: cd14091 (541 - 827)

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  • 860 a.a.
Protein Preferred Names Protein Names

ribosomal protein S6 kinase alpha-6

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12259 RPS6KA6 Human Pre-designed siRNA Set A / Unkown
HY-RS12260 Rps6ka6 Mouse Pre-designed siRNA Set A / Unkown
HY-RS12261 Rps6ka6 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rps6ka6 NCBI NCBI:27330