Gpihbp1 - GPI-anchored HDL-binding protein 1 Gene

Also Known as GPI-HBP1; 1110002J19Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 68453

Summary

Enables Lipase binding activity; lipoprotein particle binding activity; and protein transporter activity. Involved in several processes, including lipid homeostasis; positive regulation of chylomicron remnant clearance; and protein transport. Acts upstream of or within lipid transport. Located in apical plasma membrane; basolateral plasma membrane; and external side of plasma membrane. Is anchored component of plasma membrane. Human ortholog(s) of this gene implicated in familial GPIHBP1 deficiency. Orthologous to human GPIHBP1 (glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Gpihbp1 Products (3)

mRNA	Protein	Name
NM_001347039.2	NP_001333968.1	glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 isoform 2 precursor
NM_001361294.1	NP_001348223.1	glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 isoform 3 precursor
NM_026730.2	NP_081006.1	glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chylomicron binding	IMP IMP: Inferred from mutant phenotype	17403372	MGI
enables high-density lipoprotein particle binding	IDA IDA: Inferred from direct assay	12496272	MGI
enables lipase binding	IPI IPI: Inferred from physical interaction	17403372	MGI
enables lipoprotein particle binding	IMP IMP: Inferred from mutant phenotype	17403372	MGI
enables protein transporter activity	IDA IDA: Inferred from direct assay	20620994	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	17403372	MGI
NOT acts upstream of or within cholesterol transport	IDA IDA: Inferred from direct assay	12496272	MGI
involved in intracellular protein transport	IDA IDA: Inferred from direct assay	20620994	MGI
acts upstream of or within lipid transport	IDA IDA: Inferred from direct assay	12496272	MGI
involved in positive regulation of chylomicron remnant clearance	IMP IMP: Inferred from mutant phenotype	17403372	MGI
involved in positive regulation of lipoprotein lipase activity	IDA IDA: Inferred from direct assay	19542565	MGI
involved in positive regulation of lipoprotein lipase activity	IMP IMP: Inferred from mutant phenotype	17403372	MGI
involved in protein import	IDA IDA: Inferred from direct assay	20620994	MGI
involved in protein localization to cell surface	IDA IDA: Inferred from direct assay	20620994	MGI
involved in protein stabilization	IDA IDA: Inferred from direct assay	19542565	MGI
involved in transcytosis	IDA IDA: Inferred from direct assay	20620994	MGI
involved in triglyceride homeostasis	IGI IGI: Inferred from genetic interaction	19542565	MGI
involved in triglyceride homeostasis	IMP IMP: Inferred from mutant phenotype	17403372	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	20620994	MGI
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	20620994	MGI
located in cell surface	IDA IDA: Inferred from direct assay	12496272	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	17403372	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	12496272	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1	high density lipoprotein-binding protein 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P2752A	Lipoprotein Lipase, Bovine		/	Unkown
HY-P2752B	Lipoprotein Lipase, Burkholderia sp.		/	Unkown
HY-RS05640	GPIHBP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19542	Gpihbp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26038	Gpihbp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gpihbp1	NCBI	NCBI:338328