Spink2 - serine peptidase inhibitor, Kazal type 2 Gene

Also Known as HUSI-II; 1700007F22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 69982

Summary

Predicted to enable serine-type endopeptidase inhibitor activity. Involved in acrosome assembly. Acts upstream of or within several processes, including gamete generation; negative regulation of serine-type endopeptidase activity; and seminiferous tubule development. Located in acrosomal vesicle and neuron projection. Is expressed in intestine; male reproductive gland or organ; oviduct; skin; and tongue. Human ortholog(s) of this gene implicated in spermatogenic failure 29. Orthologous to human SPINK2 (serine peptidase inhibitor Kazal type 2). [provided by Alliance of Genome Resources, Apr 2022]

Spink2 Products (4)

mRNA Protein Name
NM_001289764.2 NP_001276693.2 serine protease inhibitor Kazal-type 2 isoform 1
NM_001289767.1 NP_001276696.1 serine protease inhibitor Kazal-type 2 isoform 3
NM_001289768.1 NP_001276697.1 serine protease inhibitor Kazal-type 2 isoform 4 precursor
NM_183284.3 NP_899107.1 serine protease inhibitor Kazal-type 2 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
31146259 MGI
Biological Process GO Annotation Evidence References Source
involved in acrosome assembly IMP
IMP: Inferred from mutant phenotype
28554943 MGI
acts upstream of or within fertilization IMP
IMP: Inferred from mutant phenotype
21705336 MGI
acts upstream of or within male germ cell proliferation IMP
IMP: Inferred from mutant phenotype
21705336 MGI
acts upstream of or within male gonad development IMP
IMP: Inferred from mutant phenotype
21705336 MGI
acts upstream of or within negative regulation of serine-type endopeptidase activity IDA
IDA: Inferred from direct assay
21705336 MGI
acts upstream of or within positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
24699552 MGI
acts upstream of or within seminiferous tubule development IMP
IMP: Inferred from mutant phenotype
21705336 MGI
acts upstream of or within spermatid development IMP
IMP: Inferred from mutant phenotype
21705336 MGI
involved in spermatid development IMP
IMP: Inferred from mutant phenotype
28554943 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
21705336 MGI
Cellular Component GO Annotation Evidence References Source
located in acrosomal vesicle IDA
IDA: Inferred from direct assay
21705336 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
21705336 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
24699552 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine protease inhibitor Kazal-type 2

  • acrosin-trypsin inhibitor

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991676 Eflumenibep alfa Inhibitor 97.52% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13680 SPINK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20600 Spink2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27108 Spink2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spink2 NCBI NCBI:6691