ZNF217 - zinc finger protein 217 Gene

Also Known as ZABC1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7764

About ZNF217

Cytogenetic location: 20q13.2 Genomic coordinates (GRCh38): 20:53,567,071-53,597,702 (from NCBI)

This gene has 5 transcripts (splice variants), 197 orthologues and 14 paralogues. Ubiquitous expression in urinary bladder (RPKM 14.5), spleen (RPKM 14.3) and 25 other tissues.

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in mitochondrion and nuclear speck. Part of histone deacetylase complex. [provided by Alliance of Genome Resources, Apr 2022]

ZNF217 Products (2)

mRNA Protein Name
NM_001385034.1 NP_001371963.1 zinc finger protein 217 isoform 1
NM_006526.3 NP_006517.1 zinc finger protein 217 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
17130829 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17130829 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16940172 GOA
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
18625718 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16940172 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17130829 GOA
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
18625718 GOA
Cellular Component GO Annotation Evidence References Source
part of histone deacetylase complex IDA
IDA: Inferred from direct assay
18625718 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
18625718 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF217 Protein Structure

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (67 - 86)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (128 - 150)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (156 - 178)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (218 - 238)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (376 - 397)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (486 - 508)

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  • 1048 a.a.
Protein Preferred Names Protein Names

zinc finger protein 217

ZNF217 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82978 ZNF217 Antibody (YA2723) WB Human

Related Diseases

Diseases Alias
Ovarian Serous Cystadenocarcinoma

  • Serous Cystadenoma

  • Cystadenoma Serous

  • Cystadenoma, Serous
Cystadenocarcinoma
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Ovarian Clear Cell Carcinoma

  • Clear-Cell Ovarian Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16110 ZNF217 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ZNF217 VGNC VGNC:78874
Canis familiaris ZNF217 VGNC VGNC:48674
Felis catus ZNF217 VGNC VGNC:82318
Rattus norvegicus ZNF217 RGD RGD:1308451
Bos taurus ZNF217 VGNC VGNC:57037
Mus musculus ZNF217 MGD MGI:2685408
Others ZNF217 NCBI