ACAD10 - acyl-CoA dehydrogenase family member 10 Gene
Species: Homo sapiens
About ACAD10
This gene has 24 transcripts (splice variants), 124 orthologues and 14 paralogues. Ubiquitous expression in kidney (RPKM 11.6), duodenum (RPKM 7.2) and 25 other tissues.
Summary
This gene encodes a member of the acyl-CoA dehydrogenase family of Enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Nov 2008]
ACAD10 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001136538.2 | NP_001130010.1 | acyl-CoA dehydrogenase family member 10 isoform a |
| NM_025247.6 | NP_079523.3 | acyl-CoA dehydrogenase family member 10 isoform b |
ACAD10 Protein Structure
HAD_2: Haloacid dehalogenase-like hydrolase (45 - 229)
APH: Phosphotransferase enzyme family (289 - 503)
Acyl-CoA_dh_N: Acyl-CoA dehydrogenase, N-terminal domain (664 - 787)
Acyl-CoA_dh_M: Acyl-CoA dehydrogenase, middle domain (791 - 845)
Acyl-CoA_dh_1: Acyl-CoA dehydrogenase, C-terminal domain (904 - 1052)
- 0
- 200
- 400
- 600
- 800
- 1000
- 1059 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
acyl-CoA dehydrogenase family member 10 |
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Related Diseases
| Diseases | Alias | |
|---|---|---|
| Mitochondrial Complex I Deficiency, Nuclear Type 20 |
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| Nuclear Type Mitochondrial Complex I Deficiency |
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| Mitochondrial Trifunctional Protein Deficiency |
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| Mitochondrial Complex I Deficiency, Nuclear Type 1 |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | ACAD10 | MGD | MGI:1919235 |
| Macaca mulatta | ACAD10 | VGNC | VGNC:69495 |
| Rattus norvegicus | ACAD10 | RGD | RGD:1310159 |
| Others | ACAD10 | NCBI |