ADAMTS10 - ADAM metallopeptidase with thrombospondin type 1 motif 10 Gene

Also Known as WMS; WMS1; ADAM-TS10; ADAMTS-10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 81794

About ADAMTS10

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:8,580,240-8,610,715 (from NCBI)

This gene has 14 transcripts (splice variants), 215 orthologues, 25 paralogues and is associated with 4 phenotypes. Ubiquitous expression in endometrium (RPKM 4.7), fat (RPKM 3.4) and 25 other tissues.

Summary

This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted Enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008]

ADAMTS10 Products (2)

mRNA	Protein	Name
NM_001282352.2	NP_001269281.1	A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform 2
NM_030957.4	NP_112219.3	A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform 1 preproprotein

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21402694	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in collagen-containing extracellular matrix	IDA IDA: Inferred from direct assay	21402694	GOA
located in microfibril	IDA IDA: Inferred from direct assay	21402694	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAMTS10 Protein Structure

Pep_M12B_propep

Reprolysin

TSP_1

ADAM_spacer1

TSP_1

PLAC

0
200
400
600
800
1000
1103 a.a.

Protein Preferred Names	Protein Names
A disintegrin and metalloproteinase with thrombospondin motifs 10	ADAM-TS 10

Related Diseases

Diseases	Alias
Weill-Marchesani Syndrome 1	Spherophakia-Brachymorphia Syndrome WMS1 Weill-Marchesani Syndrome, Autosomal Recessive Mesodermal Dysmorphodystrophy, Congenital Weill-Marchesani Syndrome 1, Recessive Autosomal Recessive Weill-Marchesani Syndrome Congenital Mesodermal Dysmorphodystrophy Weill-Marchesani Syndrome Weill-Marchesani Syndrome, Autosomal Dominant
Weill-Marchesani Syndrome	Gemss Syndrome Spherophakia-Brachymorphia Syndrome Marchesani-Weill Syndrome Wms Congenital Mesodermal Dystrophy Mesodermal Dysmorphodystrophy, Congenital Spherophakia Brachymorphia Syndrome Mesodermal Dysmorphodystrophy Congenital Wm Syndrome Brachydactyly-Spherophakia Syndrome Brachymorphy With Spherophakia Syndrome Congenital Mesodermal Dysmorphodystrophy Marchesani Syndrome Weill-Marchesani Syndrome, Autosomal Recessive Weill-Marchesani Syndrome, Autosomal Dominant
Myopia	Near-Sightedness Short-Sightedness Nearsightedness Nearsighted Near Vision Close Sighted Myopic Short-Sighted Near Sighted
Acromicric Dysplasia	ACMICD Acromicric Skeletal Dysplasia Dysplasia, Acromicric
Geleophysic Dysplasia	Geleophysic Dwarfism Gphysd
Isolated Ectopia Lentis	Familial Ectopia Lentis Ectopia Lentis Ectopia Lentis Syndrome Lens Subluxation Iel Congenital Ectopia Lentis Subluxation Of Lens Ectopia Lentis, Isolated Ectopia Lentis Isolated
Tracheal Stenosis	Stenosis Of Trachea
Lens Subluxation	Subluxation Of Lens
Brachydactyly
Ectopia Lentis 2, Isolated, Autosomal Recessive	ECTOL2 Ectopia Lentis, Isolated, Autosomal Recessive Autosomal Recessive Isolated Ectopia Lentis 2 Autosomal Recessive Isolated Ectopia Lentis Ectopia Lentis, Isolated Autosomal Recessive Ectopia Lentis, Isolated Autosomal Recessive, Type 2
Ectopia Lentis 1, Isolated, Autosomal Dominant	ECTOL1 Ectopia Lentis, Familial Autosomal Dominant Isolated Ectopia Lentis 1
Tracheal Disease	Tracheal Diseases Tracheal Anomaly Tracheal Disorders
Stiff Skin Syndrome	SSKS Stiff Skin
Peters-Plus Syndrome	Krause-Kivlin Syndrome Peters Plus Syndrome Peters Anomaly Irido-Corneo-Trabecular Dysgenesis PTRPLS Peters Anomaly With Short-Limb Dwarfism Peters Anomaly-Short Limb Dwarfism Syndrome Peters Anomaly With Short Limb Dwarfism Peters Congenital Glaucoma Krause-Van Schooneveld-Kivlin Syndrome Peters' Plus Syndrome Peters'-Plus Syndrome Anomaly Peters
Megalocornea	Isolated Congenital Megalocornea Congenital Anterior Megalophthalmia Anterior Megalophthalmos Mgc1 Mgcn Congenital Keratoglobus
Primary Congenital Glaucoma
Hydrophthalmos
Glaucoma 3, Primary Congenital, A	Buphthalmos Glaucoma, Congenital Congenital Glaucoma Glaucoma 3a, Primary Open Angle, Congenital, Juvenile, Or Adult Onset GLC3A Glc3 Buphthalmia Primary Congenital Glaucoma Glaucoma, Primary Open Angle, Juvenile-Onset Simple Buphthalmos Buphthalmus Glaucoma, Primary Open Angle, Adult-Onset Primary Congenital Glaucoma 3a Primary Infantile Glaucoma Type 3a Glaucoma 3a, Primary Congenital Glaucoma, Congenital, Primary, Type 3a Hydrophthalmos Cystic Eyeball
Glaucoma, Primary Open Angle	Glaucoma 1, Open Angle, E Primary Open Angle Glaucoma POAG Adult-Onset Primary Open Angle Glaucoma Chronic Simple Glaucoma GLC1E Primary Open Angle Glaucoma 1e Glaucoma, Open Angle, Primary
Hennekam Syndrome	Hennekam Lymphangiectasia Lymphedema Syndrome Hennekam Lymphangiectasia-Lymphedema Syndrome Lymphedema-Lymphangiectasia-Intellectual Disability Syndrome Lymphedem-Lymphangiectasia-Intellectual Disability Syndrome Intestinal Lymphagiectasia Lymphedema Intellectual Deficit Syndrome Lymphangiectasies And Lymphedema Hennekam Type Generalized Lymphatic Dysplasia Intestinal Lymphagiectasia-Lymphedema-Mental Retardation Syndrome
Ehlers-Danlos Syndrome	Eds Cutis Hyperelastica Elastic Skin Ehlers-Danlos Syndromes Ed Syndrome Ehlers Danlos Syndrome Ehlers Danlos Disease Eds - [Ehlers-Danlos Syndrome]
Anterior Segment Dysgenesis	Anterior Segment Developmental Anomaly Anterior Segment Mesenchymal Dysgenesis Corneal Opacification And Other Ocular Anomalies Sclerocornea With Other Ocular Anomalies Asmd Asod Anterior Segment Ocular Dysgenesis Foxe3-Related Ocular Disorder Familial Ocular Anterior Segment Mesenchymal Dysgenesis Dysgenesis, Anterior Segment Irido-Corneal Dysgenesis Axenfeld-Rieger Syndrome, Type 3
Aortic Aneurysm, Familial Thoracic 1	Thoracic Aortic Aneurysm Annuloaortic Ectasia Familial Thoracic Aortic Aneurysm And Aortic Dissection Familial Aortic Dissection Familial Taad Familial Thoracic Aortic Aneurysm Congenital Aneurysm Of Ascending Aorta Familial Aortic Aneurysm Familial Thoracic Aortic Aneurysm And Dissection Aortic Aneurysm, Thoracic AAT1 Faa1 Aortic Dissection, Familial Aortic Aneurysm, Familial Thoracic Aneurysm, Thoracic Aortic Faa Ftaad Taa Taad Cystic Medial Necrosis Of Aorta Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection Aortic Aneurysm Thoracic Familial Aortic Aneurysms Aneurysm, Aortic, Thoracic, Familial, Type 1 Aneurysm Of Thoracic Aorta Intrathoracic Aneurysm Thoracic Aorta Aneurysm Thoracic Aortic Aneurysm Without Rupture Thoracic Aneurysm Thorax Arterial Aneurysm Thoracic Artery Aneurysm Thoracic Arterial Aneurysm Thorax Aneurysm Thorax Aortic Aneurysm Dissection Of Thoracic Aorta

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00292	ADAMTS10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20225	Adamts10 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26732	Adamts10 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ADAMTS10	VGNC	VGNC:25615
Rattus norvegicus	ADAMTS10	RGD	RGD:1598320
Canis familiaris	ADAMTS10	VGNC	VGNC:37591
Macaca mulatta	ADAMTS10	VGNC	VGNC:103784
Felis catus	ADAMTS10	VGNC	VGNC:69341
Mus musculus	ADAMTS10	MGD	MGI:2449112
Others	ADAMTS10	NCBI