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PROZ - protein Z, vitamin K dependent plasma glycoprotein Gene

Also Known as PZ

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8858

About PROZ

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:113,158,648-113,172,386 (from NCBI)

This gene has 3 transcripts (splice variants), 215 orthologues, 1 paralogue and is associated with 3 phenotypes. Biased expression in liver (RPKM 5.4), kidney (RPKM 4.0) and 1 other tissue.

Summary

This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

PROZ Products (2)

mRNA	Protein	Name
NM_001256134.2	NP_001243063.1	vitamin K-dependent protein Z isoform 1 precursor
NM_003891.3	NP_003882.1	vitamin K-dependent protein Z isoform 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20427285	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PROZ Protein Structure

Gla

EGF

FXa_inhibition

Trypsin

0
100
200
300
400 a.a.

Protein Preferred Names	Protein Names
vitamin K-dependent protein Z

PROZ Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84193	Protein Z Antibody (YA3890)	WB, ELISA	Human
HY-P84193A	Protein Z Antibody (YA3890)(PBS only)	WB, ELISA	Human
HY-P85337	Protein Z Antibody (YA5029)	WB	Human

Related Diseases

Diseases	Alias
Protein Z Deficiency
Cerebral Sinovenous Thrombosis	Csvt
Coumarin Resistance	Warfarin Resistance Warfarin Sensitivity Coumadin Sensitivity Warfarin Response Poor Metabolism Of Coumarin Coumarin, Poor Metabolism Of CMRES
Brain Small Vessel Disease 2	Porencephaly 2 BSVD2 Gould Syndrome 2 Porencephaly 2, Formerly Poren2, Formerly Poren2
Palmoplantar Keratoderma, Bothnian Type	PPKB Diffuse Palmoplantar Keratoderma, Bothnian Type Bothnian Type Palmoplantar Keratoderma Keratoderma, Palmoplantar, Bothnian Type Palmoplantar Keratoderma, Nonepidermolytic
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11205	PROZ Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PROZ	RGD	RGD:1308666
Macaca mulatta	PROZ	VGNC	VGNC:76428
Bos taurus	PROZ	VGNC	VGNC:33371
Mus musculus	PROZ	MGD	MGI:1860488
Others	PROZ	NCBI