TMPRSS11D - transmembrane serine protease 11D Gene

Also Known as ASP; HAT

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9407

About TMPRSS11D

Cytogenetic location: 4q13.2 Genomic coordinates (GRCh38): 4:67,820,876-67,884,002 (from NCBI)

This gene has 8 transcripts (splice variants), 534 orthologues and 17 paralogues. Restricted expression toward esophagus (RPKM 30.2).

Summary

This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, Enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to Other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with Other substances in airway mucous or bronchial secretions. This protein facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. [provided by RefSeq, Aug 2021]

TMPRSS11D Products (1)

mRNA	Protein	Name
NM_004262.3	NP_004253.1	transmembrane protease serine 11D

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in proteolysis	IDA IDA: Inferred from direct assay	24227843	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMPRSS11D Protein Structure

SEA

Trypsin

0
100
200
300
400
418 a.a.

Protein Preferred Names	Protein Names
transmembrane protease serine 11D	adrenal secretory serine protease

TMPRSS11D Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TMPRSS11D	O60235	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	TMPRSS11D	O60235	SGTA	Homo sapiens	O43765	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TMPRSS11D Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76680	TMPRSS11D Protein, Human (HEK293, His)	O60235/NP_004253.1 (I187-I418)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Deafness, Autosomal Recessive 27	DFNB27 Autosomal Recessive Nonsyndromic Deafness 27 Autosomal Recessive Deafness 27
Severe Acute Respiratory Syndrome	Sars Sars-Cov Infection Sars-1 Sar Deficiency Sars - [Severe Acute Respiratory Syndrome]
Deafness, Autosomal Dominant 27	DFNA27 Autosomal Dominant Nonsyndromic Deafness 27 Autosomal Dominant Deafness 27 Deafness, Autosomal Dominant, 27
Intellectual Developmental Disorder, X-Linked 108	MRX108 X-Linked Intellectual Developmental Disorder 108 Mental Retardation, X-Linked 108 Mental Retardation, X-Linked, Type 108
Avian Influenza	Bird Flu Influenza In Birds Avian Flu

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14765	TMPRSS11D Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19854	Tmprss11d Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26354	Tmprss11d Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TMPRSS11D	VGNC	VGNC:107206
Felis catus	TMPRSS11D	VGNC	VGNC:66382
Mus musculus	TMPRSS11D	MGD	MGI:2385221
Bos taurus	TMPRSS11D	VGNC	VGNC:55082
Canis familiaris	TMPRSS11D	VGNC	VGNC:47629
Rattus norvegicus	TMPRSS11D	RGD	RGD:620654
Others	TMPRSS11D	NCBI