1. Anti-infection
  2. HCV
  3. HCV-IN-7 hydrochloride

HCV-IN-7 hydrochloride 

Cat. No.: HY-133018A
Handling Instructions

HCV-IN-7 hydrochloride is an orally active and potent pan-genotypic HCV NS5A inhibitor with IC50s of 3-47 pM. HCV-IN-7 hydrochloride shows a superior pan-genotypic profile and a good pharmacokinetic profile coupled with a favorable liver uptake. HCV-IN-7 hydrochloride has anti-viral activity.

For research use only. We do not sell to patients.

HCV-IN-7 hydrochloride Chemical Structure

HCV-IN-7 hydrochloride Chemical Structure

CAS No. : 1449756-87-9

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Description

HCV-IN-7 hydrochloride is an orally active and potent pan-genotypic HCV NS5A inhibitor with IC50s of 3-47 pM. HCV-IN-7 hydrochloride shows a superior pan-genotypic profile and a good pharmacokinetic profile coupled with a favorable liver uptake. HCV-IN-7 hydrochloride has anti-viral activity[1].

IC50 & Target

IC50: 3-47 pM (genotypic HCV NS5A)[1]

In Vitro

HCV-IN-7 hydrochloride inhibits GT1b (IC50=12 pM), GT2a (IC50=5 pM), GT1a (IC50=27 pM), GT3a (IC50=47 pM), GT4a (IC50=3 pM), GT6a (IC50=28 pM)[1].
HCV-IN-7 hydrochloride (10 µM) has 12%, 42%, 12% inhibition for CYP2D6, CYP2C9, CYP3A4, respectively[1].
HCV-IN-7 hydrochloride (10 µM) has cytotoxicity of 14%, 22%, 36% in Huh7, HepG2 and HEK cells, respectively[1].
HCV-IN-7 hydrochloride has a less complex central tricyclic core as novel and potent pan-genotypic NS5A inhibitors with good pharmacokinetic profile[1].

In Vivo

HCV-IN-7 hydrochloride (iv; 1 mg/kg) has a T1/2 of 2 hours, CL of 11 mL/min/kg, and a Vss of 2 L/kg for rats[1].
HCV-IN-7 hydrochloride (po; 10 mg/kg) has a Cmax of 1 μM and an AUClast of 6 μM for rats[1].
HCV-IN-7 hydrochloride (iv; 1 mg/kg) has a T1/2 of 4 hours, CL of 6 mL/min/kg, and a Vss of 2 L/kg for dog[1].
HCV-IN-7 hydrochloride (po; 10 mg/kg) has a Cmax of 5 μM and an AUClast of 49 μM for dog[1].

Molecular Weight

841.85

Formula

C₄₀H₅₀Cl₂N₈O₆S

CAS No.

1449756-87-9

SMILES

[H]Cl.[H]Cl.O=C([[email protected]](C(C)C)NC(OC)=O)N(CCC1)[[email protected]@H]1C(N2)=NC=C2C3=CC(C=C4)=C(S3)C5=C4C=C(C6=CN=C([[email protected]]7N(C([[email protected]](C(C)C)NC(OC)=O)=O)CCC7)N6)C=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

HCV-IN-7HCVHepatitis C virusorallypan-genotypicNS5Asuperiorprofilepharmacokineticanti-viralInhibitorinhibitorinhibit

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