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Cat. No.: HY-187389

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HDAC6/ERα ligand-1-C6-COOH

HDAC6/ERα ligand-1-C6-COOH is a conjugate of a target protein ligand (HY-187387) and a linker. HDAC6/ERα ligand-1-C6-COOH serves as an intermediate in the synthesis of ERα/HDAC6 dual-target PROTACs, and can be used for the synthesis of PROTAC molecules.

For research use only. We do not sell to patients.

CAS No.: 3092712-04-1
Formula: C₄₁H₄₇F₃N₂O₁₀S
Molecular Weight:816.88

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HDAC6/ERα ligand-1-C6-COOH Chemical Structure

CAS No.: 3092712-04-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3092712-04-1
Molecular Weight 816.88
Formula C₄₁H₄₇F₃N₂O₁₀S
SMILES

FC(F)(F)CN(C1=CC=C(C=C1)OCCCCCCC(O)=O)S(=O)([C@@H]2[C@@]3([H])C(C4=CC=C(C=C4)NC(CCCCCCC(O)=O)=O)=C(C5=CC=C(C=C5)O)[C@](C2)([H])O3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xin L, et al. Discovery of Effective Dual PROTAC Degraders with Synergistic Antitumor Activity for Overcoming Tamoxifen-Resistant Breast Cancer. Journal of medicinal chemistry. 2026 Jul 23;69(14):17291-17309. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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