2. Immunology/Inflammation
  3. Interleukin Related
  4. Heparin disaccharide II-S trisodium

Heparin disaccharide II-S trisodium (Compound HSH-9) is a heparin-derived disaccharide. Heparin disaccharide II-S trisodium inhibits the spontaneous secretion of proinflammatory mediators IL-8 and IL-1β in intestinal epithelial cells at the post-transcriptional stage.

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Heparin disaccharide II-S trisodium

Heparin disaccharide II-S trisodium Chemical Structure

CAS No. : 136098-05-0

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Heparin disaccharide II-S trisodium Related Antibodies

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Description

Heparin disaccharide II-S trisodium (Compound HSH-9) is a heparin-derived disaccharide. Heparin disaccharide II-S trisodium inhibits the spontaneous secretion of proinflammatory mediators IL-8 and IL-1β in intestinal epithelial cells at the post-transcriptional stage[1].

IC50 & Target[1]

IL-1β

 

IL-8

 

In Vitro

Heparin disaccharide II-S (trisodium) (0.01-100 ng/mL; 24 h) dose-dependently inhibits spontaneous IL-8 secretion from HT-29 intestinal epithelial cells, with significant inhibition starting at 0.01 ng/mL[1].
Heparin disaccharide II-S (trisodium) (0.01-100 ng/mL; 24 h) dose-dependently inhibits spontaneous IL-1β secretion from HT-29 intestinal epithelial cells, with significant inhibition starting at 0.01 ng/mL[1].
Heparin disaccharide II-S (trisodium) (0.01-100 ng/mL; 24 h) dose-dependently inhibits spontaneous IL-8 secretion from Caco-2 intestinal epithelial cells, with significant inhibition starting at 0.1 ng/mL[1].
Heparin disaccharide II-S (trisodium) (0.01-100 ng/mL; 24 h) dose-dependently inhibits spontaneous IL-1β secretion from Caco-2 intestinal epithelial cells, with significant inhibition starting at 0.1 ng/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Heparin disaccharide II-S trisodium Related Antibodies

ELISA Assay[1]

Cell Line: HT-29 intestinal epithelial cells
Concentration: 0.01-100 ng/mL
Incubation Time: 24 h
Result: Dose-dependently inhibited spontaneous IL-8 secretion, with significant inhibition (P < 0.001) observed at all tested concentrations.
Increased inhibition with rising reagent concentration, reaching near-maximal levels at 100 ng/mL.\nDose-dependently inhibited spontaneous IL-1β secretion, with significant inhibition (P < 0.001) observed at all tested concentrations.
Increased inhibition with rising reagent concentration, reaching near-maximal levels at 100 ng/mL.

ELISA Assay[1]

Cell Line: Caco-2 intestinal epithelial cells
Concentration: 0.01-100 ng/mL
Incubation Time: 24 h
Result: Dose-dependently inhibited spontaneous IL-8 secretion, with significant inhibition (P < 0.001) observed at concentrations ≥0.1 ng/mL.
Increased inhibition with rising reagent concentration, reaching near-maximal levels at 100 ng/mL.\nDose-dependently inhibited spontaneous IL-1β secretion, with significant inhibition (P < 0.001) observed at concentrations ≥0.1 ng/mL.
Increased inhibition with rising reagent concentration, reaching near-maximal levels at 100 ng/mL.
Molecular Weight

563.35

Formula

C12H16NNa3O16S2
CAS No.
SMILES

O=S(N[C@@H](C=O)[C@@H](O)[C@@H]([C@H](O)COS(=O)(O[Na])=O)O[C@@H]1OC(C(O[Na])=O)=C[C@@H]([C@H]1O)O)(O[Na])=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Heparin disaccharide II-S trisodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Heparin disaccharide II-S trisodium136098-05-0Interleukin RelatedILIL-8intestinal epithelial cellsTNF-αCaco-2proinflammatory mediatorsIL-1βHT-29glucosamineInhibitorinhibitorinhibit

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