Heparin disaccharide II-S trisodium
Heparin disaccharide II-S trisodium (Compound HSH-9) is a heparin-derived disaccharide. Heparin disaccharide II-S trisodium inhibits the spontaneous secretion of proinflammatory mediators IL-8 and IL-1β in intestinal epithelial cells at the post-transcriptional stage.
For research use only. We do not sell to patients.
- CAS No.: 136098-05-0
- Formula: C12H16NNa3O16S2
- Molecular Weight:563.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IL-1β |
IL-8 |
Heparin disaccharide II-S (trisodium) (0.01-100 ng/mL; 24 h) dose-dependently inhibits spontaneous IL-8 secretion from HT-29 intestinal epithelial cells, with significant inhibition starting at 0.01 ng/mL[1].
Heparin disaccharide II-S (trisodium) (0.01-100 ng/mL; 24 h) dose-dependently inhibits spontaneous IL-1β secretion from HT-29 intestinal epithelial cells, with significant inhibition starting at 0.01 ng/mL[1].
Heparin disaccharide II-S (trisodium) (0.01-100 ng/mL; 24 h) dose-dependently inhibits spontaneous IL-8 secretion from Caco-2 intestinal epithelial cells, with significant inhibition starting at 0.1 ng/mL[1].
Heparin disaccharide II-S (trisodium) (0.01-100 ng/mL; 24 h) dose-dependently inhibits spontaneous IL-1β secretion from Caco-2 intestinal epithelial cells, with significant inhibition starting at 0.1 ng/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT-29 intestinal epithelial cells
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Concentration:0.01-100 ng/mL
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Incubation Time:24 h
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Result:Dose-dependently inhibited spontaneous IL-8 secretion, with significant inhibition (P < 0.001) observed at all tested concentrations.
Increased inhibition with rising reagent concentration, reaching near-maximal levels at 100 ng/mL.\nDose-dependently inhibited spontaneous IL-1β secretion, with significant inhibition (P < 0.001) observed at all tested concentrations.
Increased inhibition with rising reagent concentration, reaching near-maximal levels at 100 ng/mL.
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Cell Line:Caco-2 intestinal epithelial cells
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Concentration:0.01-100 ng/mL
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Incubation Time:24 h
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Result:Dose-dependently inhibited spontaneous IL-8 secretion, with significant inhibition (P < 0.001) observed at concentrations ≥0.1 ng/mL.
Increased inhibition with rising reagent concentration, reaching near-maximal levels at 100 ng/mL.\nDose-dependently inhibited spontaneous IL-1β secretion, with significant inhibition (P < 0.001) observed at concentrations ≥0.1 ng/mL.
Increased inhibition with rising reagent concentration, reaching near-maximal levels at 100 ng/mL.
Chemical Information
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CAS No. 136098-05-0
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Molecular Weight 563.35
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Formula C12H16NNa3O16S2
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SMILES
O=S(N[C@@H](C=O)[C@@H](O)[C@@H]([C@H](O)COS(=O)(O[Na])=O)O[C@@H]1OC(C(O[Na])=O)=C[C@@H]([C@H]1O)O)(O[Na])=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Heparin disaccharide II-S trisodium Related Classifications
HY-N18952 Related Classifications
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