Heparin disaccharide III-S trisodium
Heparin disaccharide III-S trisodium (Compound SHH-7) is a heparin-derived disaccharide. Heparin disaccharide III-S trisodium acts as an inhibitor of spontaneous IL-8 and IL-1β secretion by intestinal epithelial cells. Heparin disaccharide III-S trisodium functions at the post-translational stage and does not reduce mRNA or intracellular mediator levels.
For research use only. We do not sell to patients.
- CAS No.: 136098-03-8
- Formula: C12H16NNa3O16S2
- Molecular Weight:563.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IL-1β |
IL-8 |
Heparin disaccharide III-S (0.01-100 ng/mL; 24 h) trisodium dose-dependently inhibits the spontaneous secretion of IL-8 and IL-1β by HT-29 intestinal epithelial cells, with significant inhibitory effects observed starting at a concentration of 0.01 ng/mL[1].
Heparin disaccharide III-S (0.01-100 ng/mL; 24 h) trisodium dose-dependently inhibits the spontaneous secretion of IL-8 and IL-1β by Caco-2 intestinal epithelial cells. The significant inhibitory effect on IL-8 starts at 0.1 ng/mL, while that on IL-1β starts at 0.01 ng/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT-29 intestinal epithelial cells
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Concentration:0.01-100 ng/mL
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Incubation Time:24 h
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Result:Dose-dependently inhibited spontaneous IL-8 secretion from HT-29 cells, with significant inhibition (P < 0.001) at concentrations ≥0.01 ng/mL.
Dose-dependently inhibited spontaneous IL-1β secretion from HT-29 cells, with significant inhibition (P < 0.001) at concentrations ≥0.01 ng/mL.
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Cell Line:Caco-2 intestinal epithelial cells
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Concentration:0.01-100 ng/mL
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Incubation Time:24 h
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Result:Dose-dependently inhibited spontaneous IL-8 secretion from Caco-2 cells, with significant inhibition (P < 0.001) at concentrations ≥0.1 ng/mL.
Dose-dependently inhibited spontaneous IL-1β secretion from Caco-2 cells, with significant inhibition (P < 0.001) at concentrations ≥0.01 ng/mL.
Chemical Information
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CAS No. 136098-03-8
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Molecular Weight 563.35
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Formula C12H16NNa3O16S2
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SMILES
O=S(N[C@@H](C=O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1[C@@H]([C@H](C=C(O1)C(O[Na])=O)O)OS(=O)(O[Na])=O)(O[Na])=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Heparin disaccharide III-S trisodium Related Classifications
HY-N18954 Related Classifications
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