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Cat. No.: HY-P2511

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Insulin β Chain Peptide (15-23)

Name: Insulin β Chain Peptide (15-23)
Brand: MedChemExpress
SKU: HY-P2511
Price: 95.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Insulin β Chain Peptide (15-23) is one of the earliest antigenic epitopes to which CD8 T-cells respond.

For research use only. We do not sell to patients.

Purity: 95.68%
CAS No.: 247044-67-3
Formula: C₄₄H₇₂N₁₂O₁₃S
Molecular Weight:1009.18

Storage:

Sealed storage, away from moisture and light, under nitrogen.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Insulin β Chain Peptide (15-23) Chemical Structure

CAS No.: 247044-67-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

HY-P1745

InsB (9-23)

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Insulin β Chain Peptide (15-23) is one of the earliest antigenic epitopes to which CD8 T-cells respond^[1]^[2]^[3].

In Vitro

CD8 T-cells purified from 5- to 8-week-old G9Cα^−/−.NOD mice produces IFN-γ and TNF-α in response to Insulin β Chain Peptide (15-23) (1 μg/mL, 24 h)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Insulin β Chain Peptide (15-23) (50 μg, i.p.) together with CpG 1826 oligonucleotides promotes very rapid diabetes development in G9Cα^−/−.NOD mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 247044-67-3
Appearance Solid
Molecular Weight 1009.18
Formula C₄₄H₇₂N₁₂O₁₃S
Color White to off-white
Sequence

Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Gly
Sequence Shortening

LYLVCGERG
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (260 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Amrani A, et al. Progression of autoimmune diabetes driven by avidity maturation of a T-cell population. Nature. 2000;406(6797):739-742. [Content Brief]

[2]. Takaki T, et al. Requirement for both H-2Db and H-2Kd for the induction of diabetes by the promiscuous CD8+ T cell clonotype AI4. J Immunol. 2004;173(4):2530-2541. [Content Brief]

[3]. Wong FS, et al. Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes. Diabetes. 2009 May;58(5):1156-64. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Minimum order quantity

100 mg

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Insulin β Chain Peptide (15-23)

InsB (9-23)