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Cat. No.: HY-W709448

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Oxaprozin-d10

(Synonyms: Oxaprozinum-d₁₀; Wy21743-d₁₀)

Oxaprozin-d₁₀ (Oxaprozinum-d₁₀; Wy21743-d₁₀) is the deuterium labeled Oxaprozin (HY-B0808). Oxaprozin is an orally active and potent COX inhibitor, with IC₅₀ values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB. Oxaprozin induces cell apoptosis. Oxaprozin shows anti-inflammatory activity. Oxaprozin-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties.

For research use only. We do not sell to patients.

Formula: C₁₈H₅D₁₀NO₃
Molecular Weight:303.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (247 KB)

Oxaprozin-d10 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Purity & Documentation
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Akt Isoforms :

All COX Isoforms :

All NF-κB Isoforms :

All IKK Isoforms :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled Cas 21256-18-8
Molecular Weight 303.38
Formula C₁₈H₅D₁₀NO₃
SMILES

[2H]C1=C(C([2H])=C(C([2H])=C1C2=C(OC(CCC(O)=O)=N2)C3=C(C([2H])=C(C([2H])=C3[2H])[2H])[2H])[2H])[2H]
Synonyms

Oxaprozinum-d₁₀; Wy21743-d₁₀
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.