7-Hydroxyneolamellarin A
7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. 7-Hydroxyneolamellarin A is a potent hypoxia-inducible factor-1α (HIF-1α) inhibitor. 7-Hydroxyneolamellarin A attenuates the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibits vascular epidermal growth factor (VEGF) transcriptional activity. 7-Hydroxyneolamellarin A can be used in research of cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 959662-26-1
- 分子式: C24H19NO5
- 分子量:401.41
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| T47D | IC50 |
1.9 μM
Compound: 4, 7-(R/S)-Hydroxylamellarin A
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Inhibition of HIF1 activation in T47D cells by reporter gene assay
Inhibition of HIF1 activation in T47D cells by reporter gene assay
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[PMID: 17958397] |
| T47D | IC50 |
3.7 μM
Compound: 4, 7-(R/S)-Hydroxylamellarin A
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Inhibition of 1,10-phenanthroline-induced HIF1 activation in T47D cells by reporter gene assay
Inhibition of 1,10-phenanthroline-induced HIF1 activation in T47D cells by reporter gene assay
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[PMID: 17958397] |
7-Hydroxyneolamellarin A (0-150 μM; 12 h; Hela cells, MCF-7 cells and 4T1 cells) inhibits HIF-1 signaling pathway with low cytotoxicity[1].
7-Hydroxyneolamellarin A (0-100 μM; 12 h) reduces the mRNA levels of VEGF dose-dependently in Hela cells[1].
7-hydroxyneolamellarin A (0-50 μM; 36 h) inhibits Hela cells migration, invasion and proliferation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Hela cells, MCF-7 cells and 4T1 cells
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Concentration:0, 50, 100, and 150 μM
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Incubation Time:12 hours
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Result:Decreased the HIF-1α protein levels in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c mice with 4T1 cells xenografts[1]
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Dosage:15 mg/kg
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Administration:Intravenous injection; every 2 days for 16 days
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Result:Inhibited tumor growth in vivo.
化学情報
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CAS 番号 959662-26-1
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分子量 401.41
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分子式 C24H19NO5
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SMILES
OC1=CC=C(C(O)C(N2C=C(C3=CC=C(O)C=C3)C(C4=CC=C(O)C=C4)=C2)=O)C=C1
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Structure Classification
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Initial Source
Dendrilla nigra
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
7-Hydroxyneolamellarin A 関連分類
HY-N10330 関連分類
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