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製品番号: HY-117893

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BIM-46068

BIM-46068 is a potent, selectively human brain Farnesyltransferase (FTase) inhibitor (IC₅₀ = 91.4 nM). BIM-46068 can specifically inhibit Ras processing in MiaPaCa-2 cancer cells. BIM-46068 can be used for the study of pancreatic cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 201487-53-8
分子式: C₂₁H₄₂N₄O₃S₃
分子量:494.78

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

BIM-46068 構造式

CAS 番号: 201487-53-8

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Ras アイソフォーム固有の製品をすべて表示 :

体外実験

BIM-46068 (0.1-10 µM, 48 h) specifically inhibits the processing of Ras in MiaPaCa-2 cancer cells^[1].
BIM-46068 (96 h) inhibits the growth of cells bearing the wild-type ras as well as cells with the different mutated ras (K-ras, N-ras, or H-ras) and effectively inhibits the multidrug-resistant cell line T24R^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

MiaPaCa-2 cells
Concentration:

0.1 µM, 1 µM, 10 µM
Incubation Time:

48 h
Result:

Caused a change in the electrophoretic migration rate of H-Ras protein in MiaPaCa-2 cells, from rapid migration (farnesylated form) to slow migration (unfarnesylated form).

体内実験

BIM-46068 (1-30 mg/kg, i.p., once daily for 10 days) significantly reduces tumor growth in a dose-dependent manner, and no signs of toxicity, such as weight loss or death, are observed at the highest dose (30 mg/kg)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Nude mice were implanted s.c. with MiaPaCa-2 cells (5 × 10⁶), a human pancreatic tumor cell line expressing mutated K-ras^[1].
Dosage:

1 mg/kg, 10 mg/kg, 30 mg/kg
Administration:

I.p., once daily for 10 days
Result:

Significantly reduced tumor growth in a dose-dependent manner.
On day 34 post-implantation, the mean tumor volume in the 30 mg/kg group was reduced by 50% compared to the control group.

化学情報

CAS 番号 201487-53-8
分子量 494.78
分子式 C₂₁H₄₂N₄O₃S₃
SMILES

CSCC[C@@H](C(OC)=O)NC([C@H]1N(C[C@@H](NC[C@@H](N)CS)[C@@H](C)CC)CSC1(C)C)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (279 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Prevost GP, et al. Inhibition of human tumor cell growth in vitro and in vivo by a specific inhibitor of human farnesyltransferase: BIM-46068. Int J Cancer. 1999 Oct 8;83(2):283-7. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

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BIM-46068

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