REST - RE1 silencing transcription factor Gene

Also Known as WT6; XBR; HGF5; NRSF; DFNA27; GINGF5

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 5978

About REST

Cytogenetic location: 4q12 Genomic coordinates (GRCh38): 4:56,907,900-56,935,844 (from NCBI)

This gene has 12 transcripts (splice variants), 226 orthologues, 29 paralogues and is associated with 5 phenotypes. Ubiquitous expression in bone marrow (RPKM 9.2), testis (RPKM 8.5) and 25 other tissues.

Summary

This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2018]

REST Products (3)

mRNA	Protein	Name
NM_001193508.1	NP_001180437.1	RE1-silencing transcription factor
NM_001363453.2	NP_001350382.1	RE1-silencing transcription factor
NM_005612.5	NP_005603.3	RE1-silencing transcription factor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	19342457	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10449787	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	33108349	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8568247	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	33108349	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	17130167	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10449787	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	17555596	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in cellular response to electrical stimulus	IMP IMP: Inferred from mutant phenotype	18570921	GOA
involved in cellular response to glucocorticoid stimulus	IDA IDA: Inferred from direct assay	17984088	GOA
involved in cellular response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	20564196	GOA
involved in negative regulation by host of viral transcription	IDA IDA: Inferred from direct assay	17555596	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	7697725	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	18570921	GOA
involved in negative regulation of aldosterone biosynthetic process	IMP IMP: Inferred from mutant phenotype	19342457	GOA
involved in negative regulation of amniotic stem cell differentiation	IMP IMP: Inferred from mutant phenotype	20942606	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	20564196	GOA
involved in negative regulation of cortisol biosynthetic process	IMP IMP: Inferred from mutant phenotype	19342457	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20564196	GOA
involved in negative regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	20942606	GOA
involved in negative regulation of mesenchymal stem cell differentiation	IMP IMP: Inferred from mutant phenotype	18570921	GOA
involved in negative regulation of miRNA transcription	IMP IMP: Inferred from mutant phenotype	33108349	GOA
involved in negative regulation of neuron differentiation	IDA IDA: Inferred from direct assay	21258371	GOA
involved in negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	18570921	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8568247	GOA
involved in nervous system process	IMP IMP: Inferred from mutant phenotype	24670762	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17984088	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	20564196	GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	20564196	GOA
involved in positive regulation of stem cell population maintenance	IDA IDA: Inferred from direct assay	21258371	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11779185	GOA
involved in response to hypoxia	IDA IDA: Inferred from direct assay	27531581	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in cytoplasm	IDA IDA: Inferred from direct assay	24670762	GOA
located in nucleus	IDA IDA: Inferred from direct assay	7697725	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	16442230	GOA
part of transcription repressor complex	IDA IDA: Inferred from direct assay	10734093	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

REST Protein Structure

zf-C2H2_4

zf-H2C2_2

0
200
400
600
800
1000
1097 a.a.

Protein Preferred Names	Protein Names
RE1-silencing transcription factor	neural-restrictive silencer factor

REST Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	REST	Q13127	KDM5C	Homo sapiens	P41229	Anti Bait CoIP	17468742
Intra	REST	Q13127	HSP90AA1	Homo sapiens	P07900	Y2H Pooling	31361762
Intra	REST	Q13127	HSP90AA1	Homo sapiens	P07900	Y2H	31361762
Intra	REST	Q13127	HSP90AA1	Homo sapiens	P07900	Anti Bait CoIP	31361762
Intra	REST	Q13127	BTRC	Homo sapiens	Q9Y297	Anti Bait CoIP	18354483
Intra	REST	Q13127	BTRC	Homo sapiens	Q9Y297	Anti Tag CoIP	18354483
Intra	REST	Q13127	BTRC	Homo sapiens	Q9Y297	Pull Down	18354483
Intra	REST	Q13127	BTRC	Homo sapiens	Q9Y297	Anti Bait CoIP	18354482
Intra	REST	Q13127	FBXW11	Homo sapiens	Q9UKB1	Pull Down	18354483
Intra	REST	Q13127	FBXW11	Homo sapiens	Q9UKB1	Anti Bait CoIP	18354482

Cross: Cross-species interaction Intra: Intraspecies interaction

REST 抗体

製品番号	製品名	アプリケーション	反応性
HY-P83635	REST Antibody (YA3380)	WB	Human

関連疾患

Diseases	Alias
Fibromatosis, Gingival, 5	GINGF5 Ggf5 Fibromatosis, Gingival, Hereditary, 5 Hgf5 Gingival Fibromatosis 5
Wilms Tumor 6	WT6 Wilms Tumor 6, Susceptibility To Susceptibility To Wilms Tumor 6 Wilms Tumor, Susceptibility To Nephroblastoma
Deafness, Autosomal Dominant 27	DFNA27 Autosomal Dominant Nonsyndromic Deafness 27 Autosomal Dominant Deafness 27 Deafness, Autosomal Dominant, 27
Gingival Fibromatosis	Hereditary Gingival Fibromatosis Hereditary Gingival Hyperplasia Autosomal Dominant Gingival Fibromatosis Autosomal Dominant Gingival Hyperplasia Fibromatosis, Gingival, Hereditary Fibromatosis, Gingival
Fibromatosis, Gingival, 1	GINGF1 Ggf1 Fibromatosis, Gingival, Hereditary Hgf Hereditary Gingival Fibromatosis Gingf Gingival Fibromatosis, 1 Fibromatosis Gingival, Hereditary, 1 Hgf1 Hereditary Gingival Fibromatosis, 1
Wilms Tumor Predisposition
Aging
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Fibromatosis
Prostate Neuroendocrine Neoplasm	Neuroendocrine Tumor Of The Prostate
Ischemia	Acute Coronary Syndrome
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Rett Syndrome	Atypical Rett Syndrome RTT Rett Disorder Rts Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use Rett Syndrome, Preserved Speech Variant Rett Syndrome, Atypical Rett'S Disorder Rett Syndrome Variant Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome Cerebroatrophic Hyperammonemia Rett Like Syndrome Rett'S Syndrome Atypical Rtt Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Rett Syndrome Preserved Speech Variant Rett Syndrome Zappella Variant Rett Syndrome, Zappella Variant
Down Syndrome	Trisomy 21 Complete Trisomy 21 Syndrome Down'S Syndrome Trisomy 21 Syndrome Down'S Syndrome - Trisomy 21 Downs Syndrome G Trisomy 47,Xx,+21 47,Xy,+21 Trisomy G Down Syndrome, Susceptibility To Chromosome 21 Trisomy Trisomy 21 Nos Abnormal Autosomes 21
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (14)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-B0069	Fludarabine		99.73%	Yes
HY-A0083	Methacholine chloride	Agonist	≥98.0%	Yes
HY-70057	Safinamide	Inhibitor	99.86%	Yes
HY-17001	Flupirtine Maleate		99.97%	Yes
HY-17001A	Flupirtine		99.98%	Yes
HY-70057A	Safinamide mesylate	Inhibitor	99.07%	Yes
HY-B1194	Tetramisole hydrochloride		99.04%	Unkown
HY-B0516	Articaine hydrochloride	Inhibitor	99.38%	Unkown
HY-A0083B	Methacholine bromide	Agonist	/	Unkown
HY-B0516A	Articaine	Inhibitor	/	Unkown
HY-B0516R	Articaine hydrochloride (Standard)	Inhibitor	/	Unkown
HY-B1194A	Tetramisole		/	Unkown
HY-17001R	Flupirtine Maleate (Standard)		/	Unkown
HY-B0069R	Fludarabine (Standard)		/	Unkown

Clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Phase
HY-W709349	Flupirtine hydrochloride		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (53)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-12680	PRN694	Inhibitor	≥99.0%	Unkown
HY-136833	X5050	Inhibitor	98.05%	Unkown
HY-120657	9-PAHSA		99.88%	Unkown
HY-136460	Calcium ionophore I		99.6%	Unkown
HY-W012282	3′-Deoxyuridine		98.0%	Unkown
HY-W013712	GI-530159	Activator	99.45%	Unkown
HY-Y0531	1-Adamantanol		99.64%	Unkown
HY-W040240	L-(-)-Sorbose		97.0%	Unkown
HY-149483	CVN417	Antagonist	99.93%	Unkown
HY-N0046	Notoginsenoside Fe	Inhibitor	99.99%	Unkown
HY-RS11853	REST Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-113603	Tildacerfont	Inhibitor	98.60%	Unkown
HY-103178	MRE3008F20	Antagonist	99.70%	Unkown
HY-106667	DL 071IT	Inhibitor	98.81%	Unkown
HY-142682	SCP1-IN-1	Inhibitor	98.42%	Unkown
HY-142683	SCP1-IN-2	Inhibitor	98.77%	Unkown
HY-116790B	(±)-Penbutolol	Antagonist	98.07%	Unkown
HY-70057S1	Safinamide-d4-1	Inhibitor	98.90%	Unkown
HY-P10817	Corza6	Inhibitor	97.63%	Unkown
HY-P10817A	Corza6 TFA	Inhibitor	95.53%	Unkown
HY-121628	Flusulfamide	Inhibitor	/	Unkown
HY-152901	Chol-N3		/	Unkown
HY-N10631	Paucimannose		/	Unkown
HY-W770410	9-PAHSA-13C4		99.9%	Unkown
HY-144026S	9-PAHSA-d9		/	Unkown
HY-103298	MNI-caged kainate		/	Unkown
HY-106718	Barucainide	Inhibitor	/	Unkown
HY-110230	Flupirtine-d4 hydrochloride		99.87%	Unkown
HY-125452	DiSBAC10		/	Unkown
HY-137618B	Rp-dGTPαS		/	Unkown
HY-159986	X-17	Inhibitor	/	Unkown
HY-161272	Nav1.8-IN-6	Inhibitor	/	Unkown
HY-162478	GR-28		/	Unkown
HY-181874	E0714	Activator	/	Unkown
HY-183709	Nav1.8-IN-24	Inhibitor	/	Unkown
HY-185207	CQ80	Inducer	/	Unkown
HY-A0083C	Methacholine iodide	Agonist	/	Unkown
HY-E71264	β-Acetylglucosaminidase 18A, Bacteroides thetaiotaomicron		/	Unkown
HY-P11705	PUMA2A		/	Unkown
HY-P11870	PADI4_7	Ligand	/	Unkown
HY-P5152	Scorpion toxin Tf2	Activator	/	Unkown
HY-W328882	3-(2-Aminopropyl)phenol		/	Unkown
HY-W709349S	Flupirtine-d6 hydrochloride	Activator	/	Unkown
HY-120657S	9-PAHSA-d4		/	Unkown
HY-120657S1	9-PAHSA-d31		99.00%	Unkown
HY-174754	Human CCL28 mRNA		/	Unkown
HY-174758	Human CCL24 mRNA		/	Unkown
HY-174759	Human CCL23 mRNA		/	Unkown
HY-174760	Human CCL22 mRNA		/	Unkown
HY-70057S4	Safinamide-d5	Inhibitor	/	Unkown
HY-D2482	Asante potassium green-1 AM		/	Unkown
HY-RS17141	Rest Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23588	Rest Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

阻害性抗体 (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-P991479	Amtabafusp alfa		99%	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Mus musculus	REST	MGD	MGI:104897
Rattus norvegicus	REST	RGD	RGD:621069
Macaca mulatta	REST	VGNC	VGNC:76898
Canis familiaris	REST	VGNC	VGNC:45480
Others	REST	NCBI