2. Anti-infection
  3. Fungal
  4. Flusulfamide

Flusulfamide is a sulfonanilide Fungicide that effectively inhibits the germination of resting spores of Plasmodiophora brassicae, the pathogen causing clubroot in cruciferous crops. Flusulfamide blocks the developmental process of resting spores from stage 1 to stage 2. By downregulating germination-related genes and upregulating immunophilin genes (such as PbCyp3), it induces abnormal accumulation of the PbCYP3 protein, thereby causing the spores to deplete energy in a state of continuous energy consumption without germination, and reducing their infectivity. Flusulfamide reduces soil ATP content in the early stage of application, but soil microbial biomass gradually recovers 3 days later. Flusulfamide is widely used in research on clubroot control.

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Flusulfamide

Flusulfamide Chemical Structure

CAS No. : 106917-52-6

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Flusulfamide Related Antibodies

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Description

Flusulfamide is a sulfonanilide Fungicide that effectively inhibits the germination of resting spores of Plasmodiophora brassicae, the pathogen causing clubroot in cruciferous crops. Flusulfamide blocks the developmental process of resting spores from stage 1 to stage 2. By downregulating germination-related genes and upregulating immunophilin genes (such as PbCyp3), it induces abnormal accumulation of the PbCYP3 protein, thereby causing the spores to deplete energy in a state of continuous energy consumption without germination, and reducing their infectivity. Flusulfamide reduces soil ATP content in the early stage of application, but soil microbial biomass gradually recovers 3 days later. Flusulfamide is widely used in research on clubroot control[1][2][3].

In Vitro

Flusulfamide (1 ppm; 3-6 d) inhibits the progression of primary zoospore development from stage 1 to stages 2 and 3 in resting spores of Plasmodiophora brassicae (Williams race 4) on the 3rd and 6th days post-incubation[3].
Flusulfamide (0.5-2 ppm; 5 d) downregulates 80% of the repeatedly expressed germination-related genes in resting spores of Plasmodiophora brassicae (Williams pathotype 4)[3].
Flusulfamide (1 ppm; 24 h) significantly upregulates the expression of most immunophilin genes in resting spores of Plasmodiophora brassicae (Williams pathotype 4), among which PbCYP3, PbCYP8 and PbCYP10 show upregulated expression at multiple early time points up to 24 h[3].
Flusulfamide (1 ppm; 24 h) increases the accumulation of the 17.5 kDa PbCYP3 protein in resting spores of Plasmodiophora brassicae (Williams’ race 4)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Flusulfamide Related Antibodies
Molecular Weight

415.17

Formula

C13H7Cl2F3N2O4S
CAS No.
SMILES

O=S(NC(C(Cl)=C1)=CC=C1[N+]([O-])=O)(C2=CC=C(C(C(F)(F)F)=C2)Cl)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (120.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4087 mL 12.0433 mL 24.0865 mL
5 mM 0.4817 mL 2.4087 mL 4.8173 mL
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Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4087 mL 12.0433 mL 24.0865 mL 60.2163 mL
5 mM 0.4817 mL 2.4087 mL 4.8173 mL 12.0433 mL
10 mM 0.2409 mL 1.2043 mL 2.4087 mL 6.0216 mL
15 mM 0.1606 mL 0.8029 mL 1.6058 mL 4.0144 mL
20 mM 0.1204 mL 0.6022 mL 1.2043 mL 3.0108 mL
25 mM 0.0963 mL 0.4817 mL 0.9635 mL 2.4087 mL
30 mM 0.0803 mL 0.4014 mL 0.8029 mL 2.0072 mL
40 mM 0.0602 mL 0.3011 mL 0.6022 mL 1.5054 mL
50 mM 0.0482 mL 0.2409 mL 0.4817 mL 1.2043 mL
60 mM 0.0401 mL 0.2007 mL 0.4014 mL 1.0036 mL
80 mM 0.0301 mL 0.1505 mL 0.3011 mL 0.7527 mL
100 mM 0.0241 mL 0.1204 mL 0.2409 mL 0.6022 mL
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Flusulfamide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flusulfamide106917-52-6FungalPbCyp3PbCYP3clubroot diseaseprimary zoosporogenesissoil microbial biomassimmunophilin genesresting sporesPlasmodiophora brassicaesoil ATP contentspore germinationInhibitorinhibitorinhibit

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