Flusulfamide 

Flusulfamide is a sulfonanilide Fungicide that effectively inhibits the germination of resting spores of Plasmodiophora brassicae, the pathogen causing clubroot in cruciferous crops. Flusulfamide blocks the developmental process of resting spores from stage 1 to stage 2. By downregulating germination-related genes and upregulating immunophilin genes (such as PbCyp3), it induces abnormal accumulation of the PbCYP3 protein, thereby causing the spores to deplete energy in a state of continuous energy consumption without germination, and reducing their infectivity. Flusulfamide reduces soil ATP content in the early stage of application, but soil microbial biomass gradually recovers 3 days later. Flusulfamide is widely used in research on clubroot control^[1][2][3].

Flusulfamide (1 ppm; 3-6 d) inhibits the progression of primary zoospore development from stage 1 to stages 2 and 3 in resting spores of Plasmodiophora brassicae (Williams race 4) on the 3rd and 6th days post-incubation^[3].
Flusulfamide (0.5-2 ppm; 5 d) downregulates 80% of the repeatedly expressed germination-related genes in resting spores of Plasmodiophora brassicae (Williams pathotype 4)^[3].
Flusulfamide (1 ppm; 24 h) significantly upregulates the expression of most immunophilin genes in resting spores of Plasmodiophora brassicae (Williams pathotype 4), among which PbCYP3, PbCYP8 and PbCYP10 show upregulated expression at multiple early time points up to 24 h^[3].
Flusulfamide (1 ppm; 24 h) increases the accumulation of the 17.5 kDa PbCYP3 protein in resting spores of Plasmodiophora brassicae (Williams’ race 4)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

415.17

C₁₃H₇Cl₂F₃N₂O₄S

106917-52-6

O=S(NC(C(Cl)=C1)=CC=C1[N+]([O-])=O)(C2=CC=C(C(C(F)(F)F)=C2)Cl)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Aviantara D B. The effects of fluazinam and flusulfamide on soil ATP microbial biomass[C]//Proceeding of the International Seminar on Chemistry 2008. 2008: 269-272.

  [2]. Ahn, Gyeong-geun, et al. Analytical Method for the Residues of Flusulfamide, a Benzenesulfonamide Fungicide, in Major Agricultural Products [J]. Korean J. Environ. Agric., 2018, 37(1): 57-65.

  [3]. Sasaki T, et al. Effects of flusulfamide on spore germination of Plasmodiophora brassicae[J]. Journal of Pesticide Science, 2024, 49(1): 52-57.