HDAC-IN-35
HDAC-IN-35 (Compound 14) is a potent, selective HDAC and VEGFR-2 inhibitor, with IC50 values of 0.166 and 13.2 µM for HDAC6 and VEGFR-2, respectively.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C17H13ClF3N3O3
- 分子量:399.75
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
VEGFR アイソフォーム固有の製品をすべて表示
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生物活性
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HDAC6 0.166 μM (IC50) |
HDAC8 1.99 μM (IC50) |
HDAC1 7.23 μM (IC50) |
VEGFR2 13.2 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
3.4 μM
Compound: 14
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Anticancer activity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Anticancer activity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
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[PMID: 34634618] |
| PC-3 | IC50 |
1.9 μM
Compound: 14
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Anticancer activity against human PC-3 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Anticancer activity against human PC-3 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
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[PMID: 34634618] |
| SK-HEP1 | IC50 |
3.2 μM
Compound: 14
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Anticancer activity against human SK-HEP1 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Anticancer activity against human SK-HEP1 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
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[PMID: 34634618] |
HDAC-IN-35 (Compound 14) (0-10 µM, 48 h) shows anticancer effects in different cancer cells[1].
HDAC-IN-35 (0-10 µM, 48 h) exhibits potent anti-angiogenic activity with a GI>50 (50% growth inhibition) value of 1.0 μM on human endothelial progenitor cells (EPCs) through a VEGFR-2-dependent pathway, without obvious systemic toxicity[1].
HDAC-IN-35 exhibits moderate VEGFR-2 inhibitory activities and displays the anticancer effects by inhibiting the enzymatic activity of HDAC[1].
HDAC-IN-35 (0-10 µM, 24 h) concentration-dependently impedes the capillary-like tube formation in human EPCs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549, PC-3, and SK-Hep-1
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Concentration:0-10 µM
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Incubation Time:48 h
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Result:Showed anticancer effects with IC50 values of 3.4, 1.9 and 3.2 µM against A549, PC-3, and SK-Hep-1 cells.
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Cell Line:A549, PC-3, and SK-Hep-1, and human EPCs
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Concentration:0, 5, and 10 µM
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Incubation Time:24 h
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Result:Increased the amount of acetylated α-tubulin and histone H3 in a concentration-dependent manner in cancer cells. Induced mild inhibition of the phosphorylation of VEGFR-2 in human EPCs.
化学情報
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分子量 399.75
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分子式 C17H13ClF3N3O3
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SMILES
O=C(NO)/C=C/C1=CC=C(C=C1)NC(NC2=CC=C(C(C(F)(F)F)=C2)Cl)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
HDAC-IN-35 関連分類
HY-146539 関連分類
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