PPNDS tetrasodium
Based on 1 Customer Validation
PPNDS tetrasodium is a selective and competitive meprin β inhibitor (IC50: 80 nM, Ki: 8 nM), and also inhibits ADAM10 (IC50: 1.2 μM). PPNDS tetrasodium is also a P2X1 receptor antagonist. PPNDS is an agonist for the ATP receptor of Paramecium. PPNDS tetrasodium potently inhibits polymerases from viruses. PPNDS tetrasodium can be used in the research of infection and cancers.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 89.0%
- CAS 番号: 1021868-77-8
- 分子式: C18H11N4Na4O14PS2
- 分子量:694.36
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保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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P2X Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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ADAM10 1.2 μM (IC50) |
p2x1 Receptor |
PPNDS tetrasodium inhibits meprin β (IC50: 80 nM) and meprin α (67 μM)[1].
PPNDS tetrasodium (0-10 μM, 15 min) inhibits mNV-RdRp (murine Norovirus RNA-dependent RNA-polymerase) with an IC50 value of 0.88 μM[2].
PPNDS tetrasodium (0.025-10 µM) potently inhibits polymerases from six viruses spanning the three Caliciviridae genera tested (IC50 range: 0.1-2.3 μM)[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1021868-77-8
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性状 Solid
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分子量 694.36
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分子式 C18H11N4Na4O14PS2
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Color Brown to black
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SMILES
O=CC1=C(C(C)=NC(/N=N/C2=CC(S(=O)(O[Na])=O)=C(C=C([N+]([O-])=O)C=C3S(=O)(O[Na])=O)C3=C2)=C1COP(O[Na])(O[Na])=O)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
H2O : 37.5 mg/mL (54.01 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (280 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Franck Madoux, et al. Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β. Biopolymers. 2014 Sep;102(5):396-406. [Content Brief]
[2]. Romina Croci, et al. PPNDS inhibits murine Norovirus RNA-dependent RNA-polymerase mimicking two RNA stacking bases. FEBS Lett. 2014 May 2;588(9):1720-5. [Content Brief]
[3]. Christopher R Wood, et al. PPNDS is an agonist, not an antagonist, for the ATP receptor of Paramecium. J Exp Biol. 2003 Feb;206(Pt 3):627-36. [Content Brief]
[4]. Natalie E Netzler, et al. Broad-spectrum non-nucleoside inhibitors for caliciviruses. Antiviral Res. 2017 Oct;146:65-75. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.4402 mL | 7.2009 mL | 14.4018 mL | 36.0044 mL |
| 5 mM | 0.2880 mL | 1.4402 mL | 2.8804 mL | 7.2009 mL | |
| 10 mM | 0.1440 mL | 0.7201 mL | 1.4402 mL | 3.6004 mL | |
| 15 mM | 0.0960 mL | 0.4801 mL | 0.9601 mL | 2.4003 mL | |
| 20 mM | 0.0720 mL | 0.3600 mL | 0.7201 mL | 1.8002 mL | |
| 25 mM | 0.0576 mL | 0.2880 mL | 0.5761 mL | 1.4402 mL | |
| 30 mM | 0.0480 mL | 0.2400 mL | 0.4801 mL | 1.2001 mL | |
| 40 mM | 0.0360 mL | 0.1800 mL | 0.3600 mL | 0.9001 mL | |
| 50 mM | 0.0288 mL | 0.1440 mL | 0.2880 mL | 0.7201 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
PPNDS tetrasodium 関連分類
HY-108675 関連分類
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