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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
938 Results for "
trans-
" in MedChemExpress (MCE) Product Catalog:
Products (938)
938 Results for "trans-" in MCE Product Catalog:
259
259 Publications Verification
別名: ICI 47699; (Z)-Tamoxifen; trans-Tamoxifen
Target:
Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively. Tamoxifen activates autophagy and induces apoptosis. Tamoxifen can also be dissolved in corn oil (HY-Y1888) for use in inducing gene knockout in CreER transgenic mice. Tamoxifen has better solubility in corn oil compared to Tamoxifen Citrate (HY-13757) .
259
259 Publications Verification
別名: ICI 46474; (Z)-Tamoxifen Citrate; trans-Tamoxifen Citrate
Target:
Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells.Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively. Tamoxifen Citrate activates autophagy and induces apoptosis. Tamoxifen Citrate can also be used to induce gene knockout in CreER transgenic mice .
172
146
146 Cited Publications
別名: Vitamin A acid; all-trans-Retinoic acid; ATRA
59
59 Cited Publications
製品番号: HY-16950
CAS 番号: 68047-06-3
別名: (Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen; (Z)-Afimoxifene
Target:
研究分野:
4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) is an orally active, selective estrogen receptor modulator (SERM). 4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) is also the active metabolic form of Tamoxifen (HY-13757A) in vivo and can be used to induce gene knockout in transgenic mice expressing CreER .
47
47 Cited Publications
研究分野:
ISRIB (trans-isomer) is a potent inhibitor of PERK with an IC50 of 5 nM. ISRIB potently reverses the effects of eIF2α phosphorylation (IC50=5 nM).
45
45 Cited Publications
製品番号: HY-P9917
CAS 番号: 375823-41-9
別名: Anti-Human IL6R, Humanized Antibody; RG-1569; rhPM-1
Target:
26
26 Cited Publications
別名: Astringenin; trans-Piceatannol
Category:
Microorganisms Rheum palmatum L. Stilbenes Polygonaceae Plants Disease Research Fields Cancer
Target:
22
Target:
研究分野:
Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA) which increases intracellular levels of endogenous all-trans retinoic acid (RA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM, respectively.
14
9
Target:
ML-SI3 is a mixture of cis/trans ML-SI3 (HY-139426A), which is a TRPML1/2 channel inhibitor with IC50s of 4.7 μM and 1.7 μM, respectively. ML-SI3 also inhibits lysosomal calcium efflux and blocks downstream TRPML1-mediated autophagy. The cis/trans ML-SI3 (HY-139426A) components of ML-SI3 are TRPML2 activators with EC50s of 3.3 μM and 9.4 μM, respectively .
9
7
7 Cited Publications
製品番号: HY-W019711
CAS 番号: 14371-10-9
7
Category:
Target:
6
6 Cited Publications
別名: Erythrosphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine
Target:
6
6 Cited Publications
製品番号: HY-W089922
CAS 番号: 2673-72-5
別名: Erythrosphingosine hydrochloride; erythro-C18-Sphingosine hydrochloride; trans-4-Sphingenine hydrochloride
Category:
Target:
6
6 Cited Publications
別名: (-)-(E)-Caryophyllene; (−)-β-caryophyllene; (−)-trans-Caryophyllene
5
Category:
Plants Endogenous metabolite other families Microorganisms Monophenols Simple Phenylpropanols Phenols Phenylpropanoids Disease Research Fields Cancer
Target:
5
5 Cited Publications
製品番号: HY-118861
CAS 番号: 15690-57-0
別名: (E)-Clomiphene; trans-Clomiphene; Enclomifene
Target:
Enclomiphene ((E)-Clomiphene) is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes .
5
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
