製品番号: HY-113016

エライジン酸

(別名: Elaidic acid)

5 Cited Publications

カスタマーレビュー

Based on 5 publication(s) in Google Scholar

Elaidic acid is an orally active trans fatty acid. Elaidic acid enhances the stemness of colorectal cancer cells by activating the Wnt/ERK1/2 pathway, thereby promoting cell proliferation, invasion and metastasis, and inhibiting apoptosis. Elaidic acid also inhibits the growth of Lactobacillus and alters the cell surface hydrophobicity of Lactobacillus. Elaidic acid reduces basal 2-deoxyglucose uptake in muscle cells and adipocytes. Elaidic acid can be used in research on colorectal cancer, insulin and other related areas.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.81%
CAS 番号: 112-79-8
分子式: C₁₈H₃₄O₂
分子量:282.46

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Elaidic acid 構造式

CAS 番号: 112-79-8

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
- 臨床実験
化学情報
Publications (5)
溶剤 & 溶解度
- 体外
- 体内
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target^[3]

IL-15

Wnt アイソフォーム固有の製品をすべて表示 :

ERK アイソフォーム固有の製品をすべて表示 :

Interleukin Related アイソフォーム固有の製品をすべて表示 :

体外実験

Elaidic acid (0-35 μM; 24-48 h) dose-dependently promotes the growth, reduces the apoptosis and enhances the invasive ability of CT26 and HT29 colorectal cancer cells^[1].
Elaidic acid (35 μM; 1 week) enhances the sphere-forming capacity of CT26 colorectal cancer cells under concurrent treatment, pre-treatment, and hypoxic conditions^[1].
Elaidic acid upregulates the expression of stem cell markers (nucleostemin, CD133, Oct4) and dedifferentiation marker (c-Myc), while downregulates the expression of differentiation markers (MUC1, MUC2, CDX2) in CT26 colorectal cancer spheres^[1].
Elaidic acid (0-500 mg/L; 0-24 h) inhibits the growth of L. rhamnosus, L. paracasei, L. zeae, <L. acidophilus and L. plantarum, but exerts no effect on the growth of L. casei^[2].
Elaidic acid (200 mg/L; 0-24 h) reduces the cell surface hydrophobicity of L. paracasei and L. casei^[2].
Elaidic acid (20-500 μM; 24 h) dose-dependently upregulates the mRNA level of TNF-α, decreases the mRNA level of IL-15, and does not enhance insulin-stimulated glucose uptake in differentiated C2C12 myotubes^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[3]

Cell Line:

C2C12 myotubes
Concentration:

20, 100, 500 μM
Incubation Time:

24 h
Result:

Reduced the mRNA levels of IL-15.
Did not affect IL-6 levels.
Increased TNF-α mRNA levels.

体内実験

Elaidic acid (10 mg/mouse; i.p.) promotes the growth and metastasis of CRC tumors in BALB/c mice and upregulates the expression of tumor differentiation markers^[1].
Elaidic acid (0-0.2 mg/kg; i.g.; every 7 days; 4 weeks) increases the number of liver CRC metastatic foci and CD133-positive cells in BALB/c mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c (male, 5 weeks old)^[1]
Dosage:

10 mg/mouse
Administration:

i.p.
Result:

Increased subcutaneous CT26 or HT29 tumor growth.
Enhanced peritoneal metastasis size of CT26 or HT29 cells.
Enhanced liver metastasis of CT26 or HT29 cells.
Enhanced lung metastasis of CT26 or HT29 cells.
Increased expression of differentiation markers MUC1, MUC2, and CDX2.

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 112-79-8
性状 Solid
分子量 282.46
分子式 C₁₈H₃₄O₂
Color White to off-white
SMILES

CCCCCCCC/C=C/CCCCCCCC(O)=O
別名

Elaidic acid
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (5)

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Journal Impact Factor

Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
J Exp Clin Cancer Res

DHRS2 mediates cell growth inhibition induced by Trichothecin in nasopharyngeal carcinoma. [Abstract]

2019 Jul 10;38(1):300. PMID: 31291971
Cell Rep Med

High-fat diet increases circulating palmitic acid produced by gut Bacteroides thetaiotaomicron to promote thrombosis. [Abstract]

2025 Aug 19;6(8):102260. PMID: 40749683
Cancer Lett

Targeting C/EBPβ/SCD1/C16:1 loop-driven macrophage M2 polarization by Bruceine D improves anti-PD-1 immunotherapy in colorectal cancer. [Abstract]

2026 Sep 28:656:218655. PMID: 42250753
Oncogene

ACSL5 regulated acetyl-CoA to promote bladder cancer cellular senescence via 53BP1 acetylation. [Abstract]

2025 Sep;44(34):3096-3112. PMID: 40595416

溶剤 & 溶解度

体外:

Ethanol : ≥ 100 mg/mL (354.03 mM)

DMSO : 13.5 mg/mL (47.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.5403 mL

17.7016 mL

35.4032 mL

5 mM

0.7081 mL

3.5403 mL

7.0806 mL

10 mM

0.3540 mL

1.7702 mL

3.5403 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 1.35 mg/mL (4.78 mM); Clear solution

This protocol yields a clear solution of ≥ 1.35 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (13.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
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COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
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OR (2659 KB)
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取扱説明書 (2659 KB)

参考文献

[1]. Ohmori H, et al. Elaidic Acid, a Trans-Fatty Acid, Enhances the Metastasis of Colorectal Cancer Cells. Pathobiology. 2017;84(3):144-151. [Content Brief]

[2]. Wu Q, et al. Effects of elaidic acid, a predominant industrial trans fatty acid, on bacterial growth and cell surface hydrophobicity of lactobacilli. J Food Sci. 2014;79(12):M2485-M2490. [Content Brief]

[3]. Granados N, et al. Distinct effects of oleic acid and its trans-isomer elaidic acid on the expression of myokines and adipokines in cell models. Br J Nutr. 2011;105(8):1226-1234. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / Ethanol	1 mM	3.5403 mL	17.7016 mL	35.4032 mL	88.5081 mL
	5 mM	0.7081 mL	3.5403 mL	7.0806 mL	17.7016 mL
	10 mM	0.3540 mL	1.7702 mL	3.5403 mL	8.8508 mL
	15 mM	0.2360 mL	1.1801 mL	2.3602 mL	5.9005 mL
	20 mM	0.1770 mL	0.8851 mL	1.7702 mL	4.4254 mL
	25 mM	0.1416 mL	0.7081 mL	1.4161 mL	3.5403 mL
	30 mM	0.1180 mL	0.5901 mL	1.1801 mL	2.9503 mL
	40 mM	0.0885 mL	0.4425 mL	0.8851 mL	2.2127 mL
Ethanol	50 mM	0.0708 mL	0.3540 mL	0.7081 mL	1.7702 mL
	60 mM	0.0590 mL	0.2950 mL	0.5901 mL	1.4751 mL
	80 mM	0.0443 mL	0.2213 mL	0.4425 mL	1.1064 mL
	100 mM	0.0354 mL	0.1770 mL	0.3540 mL	0.8851 mL

Keywords

Elaidic acid

5 Cited Publications

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エライジン酸

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MedChemExpress（MCE）の使用を引用している文献 Elaidic acid

Wnt アイソフォーム固有の製品をすべて表示

ERK アイソフォーム固有の製品をすべて表示

Interleukin Related アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (5)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Elaidic acid 関連分類

HY-113016 関連分類