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Tocilizumab

(別名: Anti-Human IL6R, Humanized Antibody; RG-1569; rhPM-1)
47 Cited Publications
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Based on 47 publication(s) in Google Scholar

Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis. Tocilizumab is remarkablely effective for the study of severe COVID-19 (coronavirus disease).

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  • 純度: 99.47%
  • CAS 番号: 375823-41-9
  • 分子量:145.2 kDa
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Tocilizumab
  • Experimental Validation Results for Tocilizumab
  • Experimental Validation Results for Tocilizumab
  • Experimental Validation Results for Tocilizumab
  • Experimental Validation Results for Tocilizumab
  • Experimental Validation Results for Tocilizumab
  • Experimental Validation Results for Tocilizumab
  • Experimental Validation Results for Tocilizumab
  • Tocilizumab Chemical Structure
    Tocilizumab 構造式
CAS 番号: 375823-41-9
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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MedChemExpress（MCE）の使用を引用している文献 Tocilizumab

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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized Human IL-6Ra/CD126, His Tag can bind Tocilizumab. The EC50 for this effect is 30.32 ng/mL.

  • 1/16

    Flow cytometry analysis of IL-6R expression U937 cells labelling IL-6R with Tocilizumab at 10nM (Red), 20ng/mL of FcγRI (CD64), FcγRII (CD32), and FcγRIII (CD16) were added to block the binding of Fc of antibody to cells respectively. Goat anti human IgG Fc(Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).

  • 1/16

    Tocilizumab purchased from MedChemExpress. Usage Cited in: ACS Nano. 2025 Sep 16;19(36):32361-32373. [Abstract]

    Customer Validation
     Representative images of fibrosis-induced spheroids subjected to microfluidic deformation analysis, comparing untreated control, antifibrotic drug NTD, and anti-interleukin drugs TCZ, STX, DUP, and TRA. Mab (5 μg/mL, 1 d) were added, Scale bars indicate 100 μm.

  • 1/16

    Tocilizumab purchased from MedChemExpress. Usage Cited in: ACS Nano. 2025 Sep 16;19(36):32361-32373. [Abstract]

    Customer Validation
     IL-6 concentrations of fibrosis-induced spheroids measured in culture supernatants following drug treatments. Tocilizumab (TCZ, 5 μg/mL, 1 d) were added.

  • 1/16

    Tocilizumab purchased from MedChemExpress. Usage Cited in: ACS Nano. 2025 Sep 16;19(36):32361-32373. [Abstract]

    Customer Validation
     TGF-β concentrations of fibrosis-induced spheroids measured in culture supernatants following drug treatments. Tocilizumab (TCZ, 5 μg/mL, 1 d) were added.

  • 1/16

    Tocilizumab purchased from MedChemExpress. Usage Cited in: ACS Nano. 2025 Sep 16;19(36):32361-32373. [Abstract]

    Customer Validation
     Confocal fluorescence images showing the expression of collagen-1 and α-SMA in spheroids treated with NTD, TCZ, STX, DUP, and TRA. Mab (5 μg/mL, 1 d) were added, Scale bars indicate 100 μm.

  • 1/16

    Tocilizumab purchased from MedChemExpress. Usage Cited in: ACS Nano. 2025 Sep 16;19(36):32361-32373. [Abstract]

    Customer Validation
     Relative mRNA expression level of α-SMA in spheroids treated with NTD and TCZ, normalized to glyceraldehyde 3-phosphate dehydrogenase (GAPDH) expression (n = 3). Tocilizumab (TCZ, 5 μg/mL, 1 d) were added.

  • Tocilizumab Chemical Structure
    1/16
  • Tocilizumab
  • Immobilized Human IL-6Ra/CD126, His Tag can bind Tocilizumab. The EC50 for this effect is 30.32 ng/mL.
  • Flow cytometry analysis of IL-6R expression U937 cells labelling IL-6R with Tocilizumab at 10nM (Red), 20ng/mL of FcγRI (CD64), FcγRII (CD32), and FcγRIII (CD16) were added to block the binding of Fc of antibody to cells respectively. Goat anti human IgG Fc(Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).