SIRT2-IN-9
Based on 1 Customer Validation
SIRT2-IN-9 (compound 12) is a selective inhibitor of SRIT2 with an IC50 value of 1.3 μM. SIRT2-IN-9 inhibits proliferative activity of MCF-7 breast cancer cells. SIRT2-IN-9 can be used for the research of cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.45%
- CAS 番号: 522650-91-5
- 分子式: C21H22N6OS2
- 分子量:438.57
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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SIRT2 1.3 μM (IC50) |
SIRT1 ＞300 μM (IC50) |
SIRT3 ＞300 μM (IC50) |
SIRT2-IN-9 (1-100 μM; 15 min) dose-dependently inhibits SRIT2 with an IC50 value of 1.3 μM, and inhibits SRIT1 and SRIT3 with IC50s ＞300 μM[1]. SIRT2-IN-9 (0-50 μM; 72 h) affects cell viability of MCF-7 cells[1]. SIRT2-IN-9 (0-50 μM; 6 h) affects acetylation of α-tubulin protein[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 breast cancer cell line
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Concentration:0-50 μM
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Incubation Time:72 hours
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Result:Dose-dependently inhibited cell proliferation of MCF-7 breast cancer cells.
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Cell Line:MCF-7 breast cancer cell line
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Concentration:6.25, 12.5, 25 and 50 μM
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Incubation Time:6 hours
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Result:Dose-dependently increased acetylation of α-tubulin protein.
化学情報
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CAS 番号 522650-91-5
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性状 Solid
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分子量 438.57
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分子式 C21H22N6OS2
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Color Light yellow to yellow
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SMILES
O=C(NC1=NC(CCCC2)=C2S1)CSC3=NN=C4C(N(CCC)C5=C4C=CC=C5)=N3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
DMSO : 4.46 mg/mL (10.17 mM; ultrasonic and warming and heat to 70°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2801 mL | 11.4007 mL | 22.8014 mL | 57.0034 mL |
| 5 mM | 0.4560 mL | 2.2801 mL | 4.5603 mL | 11.4007 mL | |
| 10 mM | 0.2280 mL | 1.1401 mL | 2.2801 mL | 5.7003 mL |
SIRT2-IN-9 関連分類
HY-151519 関連分類
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