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Scopolin 

Cat. No.: HY-N0341 Purity: 99.93%
COA Handling Instructions

Scopolin is a coumarin isolated from Arabidopsis thaliana (Arabidopsis) roots. Scopolin attenuated hepatic steatosis through activation of SIRT1-mediated signaling cascades.

For research use only. We do not sell to patients.

Scopolin Chemical Structure

Scopolin Chemical Structure

CAS No. : 531-44-2

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 259 In-stock
Solution
10 mM * 1 mL in DMSO USD 259 In-stock
Solid
5 mg USD 151 In-stock
10 mg USD 235 In-stock
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Description

Scopolin is a coumarin isolated from Arabidopsis thaliana (Arabidopsis) roots[1]. Scopolin attenuated hepatic steatosis through activation of SIRT1-mediated signaling cascades[2].

IC50 & Target[2]

SIRT1

 

In Vitro

Scopolin (100 μM, 24 h) inhibits oleic acid-induced lipid accumulation by increasing SIRT1 activity in HepG2 cells[2].
Scopolin(10 μM, 5 days) inhibits RANKL induced differentiation of preosteoclastic RAW 264.7 cells into osteoclasts[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Scopolin (0.02% (w/w) in HFD diet, 8 weeks) decreases the body weight gain, and alleviates hepatic steatosis in HFD-fed mice[2].
Scopolin (2 μmol, icv) increases the extracellular acetylcholine concentration in rat brain to about 300% compared to basal release[3].
Scopolin (50, 100 mg/kg, i.p.) inhibits adjuvant-induced arthritis by inhibiting inflammation and angiogenesis in rats[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HFD-fed C57BL/6 N mice[2]
Dosage: 0.02% (w/w) in HFD diet (equivalent to 20 mg/kg body weight)
Administration: Supplemented in diet, 8 weeks
Result: Reversed the HFD-induced hepatic TG, cholesterol, and fatty acid accumulation by 35%, 49%, and 35%, respectively.
Reversed the HFD-induced decrease in plasma adiponectin levels by 76%, and reduced the increased plasma MCP-1, TNFα, and IL-6 levels.
Restored HFD-induced downregulation of SIRT1 activity.
Animal Model: Adjuvant-induced arthritis (AIA) rats[4]
Dosage: 50, 100 mg/kg
Administration: i.p.
Result: Inhibited inoculated and non-inoculated paw swelling and articular index scores.
Reduced new blood vessels, and reduced IL-6, VEGF and FGF-2 expressions in rat synovial tissues.
Molecular Weight

354.31

Appearance

Solid

Formula

C16H18O9

CAS No.
SMILES

O=C1C=CC2=CC(OC)=C(O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)C=C2O1

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (282.24 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8224 mL 14.1119 mL 28.2239 mL
5 mM 0.5645 mL 2.8224 mL 5.6448 mL
10 mM 0.2822 mL 1.4112 mL 2.8224 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (7.06 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (7.06 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (7.06 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.93%

References
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Scopolin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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