STAT3-IN-47
STAT3-IN-47 is an orally active STAT3 inhibitor. STAT3-IN-47 exhibits broad-spectrum anti-tumor activity against HeLa, HepG2, U87, and LN229 cells. STAT3-IN-47 suppresses STAT3 activation in vitro. STAT3-IN-47 can be used for the study of solid tumors, especially central nervous system (CNS) malignancies and hepatocellular carcinoma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2787548-58-5
- 分子式: C15H8N4O3S
- 分子量:324.31
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
STAT3 |
体外実験
STAT3-IN-47 (Compound S1) (0.1-10 μM) exhibits broad-spectrum anti-tumor activity against HeLa, HepG2, U87, and LN229 cells, with IC50 values of 5.066 μM, 0.8089 μM, 1.970 μM, and 1.412 μM respectively[1].
STAT3-IN-47 (0.1-10 μM) suppresses STAT3 activation in a dose-dependent manner in HeLa, HepG2, U87, and LN229 cells[1].
STAT3-IN-47 (0.5-2 μM) inhibits EGF-induced STAT3 phosphorylation (Y705) in HeLa cells and dose-dependently suppresses IL-6-induced STAT3 phosphorylation (Y705) in HepG2, U87, LN229 cells[1].
STAT3-IN-47 downregulates stemness-associated genes (Nanog, Oct4, β-catenin) in Huh7, LN229, and HepG2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
化学情報
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CAS 番号 2787548-58-5
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分子量 324.31
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分子式 C15H8N4O3S
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SMILES
O=C(C1=C2OC(/C=N/N3C=NNC3=S)=C1)C4=C(C2=O)C=CC=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
STAT3-IN-47 関連分類
HY-178140 関連分類
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