VIPhyb
Based on 1 Customer Validation
VIPhyb is a vasoactive intestinal polypeptide (VIP) receptor antagonist. VIPhyb can inhibit VIP signaling, increase T-cell immunity and downregulate PD1. VIPhyb can inhibit cancer cell proliferation. VIPhyb can reduce inflammatory cytokine expression. VIPhyb can enhance viral clearance. VIPhyb can be used for the researches of cancer, infection and inflammation and immunology, such as non-small cell lung cancer (NSCLC), cytomegalovirus infection and colitis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.82%
- CAS 番号: 125093-93-8
- 分子式: C154H257N49O40S
- 分子量:3467.06
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
VIPhyb shows an IC50 of 500 nM against NCI-H1299 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
VIPhyb (0.1-1 μM, i.p., daily for 11 days) reduces inflammation in dextran sodium sulfate (DSS) (HY-116282C)-induced colitis mice models[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Murine cytomegalovirus (mCMV) -infected C57BL/6 and BALB/c mice[2]
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Dosage:10 μg/mouse
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Administration:Subcutaneously injection, daily for 1 week starting the day prior to infection
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Result:Prolonged survival of mice.
Had less inflammation and tissue damage in the liver.
Decreased intranuclear viral inclusions, inflammatory leukocytes, necrosis, and CMV-infected giant cells.
Increased the numbers of effector/memory CD8+ T-cells and mature NK cells were.
Prevented the up-regulation of PD-L1.
Increased CD80, CD86, and MHC-II expression.
Increased numbers of IFN-γ- and TNF-α-expressing NK cells and T-cells.
Decreased the percentage of Treg cells and levels of serum VEGF.
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Animal Model:Dextran sodium sulfate (DSS)-induced colitis mice models[3]
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Dosage:0.1 and 1 μM
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Administration:Intraperitoneally injection, daily for 11 days
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Result:Led to a significant reduction of weight loss percentage and bloody diarrhea.
Reduced colonic weight/length ratio.
Decreased expression of IL-1, TNF-α, and IL-6.
化学情報
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CAS 番号 125093-93-8
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性状 Solid
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分子量 3467.06
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分子式 C154H257N49O40S
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Color White to off-white
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配列
Lys-Pro-Arg-Arg-Pro-Tyr-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
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シーケンスの短縮
KPRRPYTDNYTRLRKQMAVKKYLNSILN-NH2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : 100 mg/mL (28.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 100 mg/mL (28.84 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (283 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
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- Español - ES (254 KB)
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- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Moody TW, et al. (Stearyl, Norleucine17)VIP hybrid antagonizes VIP receptors on non-small cell lung cancer cells. Life Sci. 1997;61(17):1657-66. [Content Brief]
[2]. Li JM, et al. VIPhyb, an antagonist of vasoactive intestinal peptide receptor, enhances cellular antiviral immunity in murine cytomegalovirus infected mice. PLoS One. 2013 May 27;8(5):e63381. [Content Brief]
[3]. Vu JP, et al. Inhibition of vasoactive intestinal polypeptide (VIP) induces resistance to dextran sodium sulfate (DSS)-induced colitis in mice. J Mol Neurosci. 2014 Jan;52(1):37-47. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 0.2884 mL | 1.4421 mL | 2.8843 mL | 7.2107 mL |
| 5 mM | 0.0577 mL | 0.2884 mL | 0.5769 mL | 1.4421 mL | |
| 10 mM | 0.0288 mL | 0.1442 mL | 0.2884 mL | 0.7211 mL | |
| 15 mM | 0.0192 mL | 0.0961 mL | 0.1923 mL | 0.4807 mL | |
| 20 mM | 0.0144 mL | 0.0721 mL | 0.1442 mL | 0.3605 mL | |
| 25 mM | 0.0115 mL | 0.0577 mL | 0.1154 mL | 0.2884 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
VIPhyb 関連分類
HY-P5005 関連分類
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