XAT-14
Based on 1 Customer Validation
XAT-14 is a Furanocoumarin derivative. XAT-14 competes with agonists to bind to the active pocket of MRGPRX2, inhibiting calcium influx and mast cell degranulation. XAT-14 suppresses the release of histamine, IL-8 and MCP-1 induced by Compound 48/80 (HY-115768). XAT-14 inhibits local allergic inflammation. XAT-14 can be used for the research of pseudo-allergic diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.50%
- CAS 番号: 3107904-59-3
- 分子式: C21H18O5
- 分子量:350.36
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Calcium Channel アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
[1]|
IL-8 |
体外実験
XAT-14 (100 μM) shows no cytotoxicity in LAD2 cells[1].
XAT-14 (25-100 μM) potently inhibits Compound 48/80-induced β-hexosaminidase release in LAD2 cells, with an IC50 of 22.95 μM, and exhibits superior efficacy to Imperatorin (HY-N0285)[1].
XAT-14 (25-100 μM) dose-dependently inhibits Compound 48/80-induced release of histamine, IL-8 and MCP-1 in LAD2 cells[1].
XAT-14 (25-100 μM) inhibits Compound 48/80-induced calcium influx in MRGPRX2-HEK293 cells in a dose-dependent manner, indicating that its effect is mediated through the MRGPRX2 signaling pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 3107904-59-3
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性状 Oil
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分子量 350.36
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分子式 C21H18O5
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Color Off-white to light yellow
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SMILES
O=C1OC2=C(OCCCOCC3=CC=CC=C3)C4=C(C=CO4)C=C2C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (285.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 5 mg/mL (14.27 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8542 mL | 14.2710 mL | 28.5421 mL | 71.3552 mL |
| 5 mM | 0.5708 mL | 2.8542 mL | 5.7084 mL | 14.2710 mL | |
| 10 mM | 0.2854 mL | 1.4271 mL | 2.8542 mL | 7.1355 mL | |
| 15 mM | 0.1903 mL | 0.9514 mL | 1.9028 mL | 4.7570 mL | |
| 20 mM | 0.1427 mL | 0.7136 mL | 1.4271 mL | 3.5678 mL | |
| 25 mM | 0.1142 mL | 0.5708 mL | 1.1417 mL | 2.8542 mL | |
| 30 mM | 0.0951 mL | 0.4757 mL | 0.9514 mL | 2.3785 mL | |
| 40 mM | 0.0714 mL | 0.3568 mL | 0.7136 mL | 1.7839 mL | |
| 50 mM | 0.0571 mL | 0.2854 mL | 0.5708 mL | 1.4271 mL | |
| 60 mM | 0.0476 mL | 0.2379 mL | 0.4757 mL | 1.1893 mL | |
| 80 mM | 0.0357 mL | 0.1784 mL | 0.3568 mL | 0.8919 mL | |
| 100 mM | 0.0285 mL | 0.1427 mL | 0.2854 mL | 0.7136 mL |
XAT-14 関連分類
HY-184281 関連分類
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