Levomilnacipran hydrochloride
Based on 1 publication(s) in Google Scholar
Levomilnacipran ((1S,2R)-Milnacipran) hydrochloride is the enantiomer of Milnacipran (HY-B0168) and a strong substrate of P-gp that can cross the blood-brain barrier. Levomilnacipran hydrochloride is a serotonin and norepinephrine reuptake inhibitor, with IC50 values of 10.5 nM and 19.0 nM, and Ki values of 92.2 nM and 1.2 nM for human norepinephrine transporter (NET) and serotonin transporter (SERT), respectively. Levomilnacipran hydrochloride has antidepressant and anxiolytic activities. Levomilnacipran hydrochloride can be used for the research of depression.
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- Purity: 99.95%
- CAS No.: 175131-60-9
- 화학식: C15H23ClN2O
- 분자량:282.81
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보관:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Levomilnacipran hydrochloride
More
Biological Activity
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TrkB |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male Wistar rats aged 9 weeks old (200-220 g) treated LPS (HY-D1056)[3]
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Dosage:30 mg/kg
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Administration:Intraperitoneal injection; 10 days
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Result:Significantly ameliorated depression-like behaviors, including increasing sucrose preference in the SPT, reducing immobility time and increasing swimming time in the FST, and increasing the time spent in the central area in the OFT.
Improved neuronal synaptic deficits and morphological changes in the hippocampus, upregulated the expression of synaptic-related proteins PSD-95 and Syn, activated the BDNF/TrkB mediated PI3K/Akt/mTOR signaling pathway, and suppressed neuroinflammation by regulating the balance of pro- and anti-inflammatory cytokines in the hippocampus.
Chemical Information
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CAS No. 175131-60-9
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Appearance Solid
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분자량 282.81
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화학식 C15H23ClN2O
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Color White to off-white
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SMILES
O=C([C@]1(C2=CC=CC=C2)[C@H](CN)C1)N(CC)CC.Cl
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Synonyms
(1S,2R)-Milnacipran hydrochloride; F-2695 hydrochloride
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell
2025 Nov 26;188(24):6861-6872.e14. PMID: 41138730
용액&용해도
H2O : ≥ 50 mg/mL (176.80 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (353.59 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
순도&문서
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Data Sheet (278 KB)
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SDS (583 KB)
- English - EN (583 KB)
- Français - FR (583 KB)
- Deutsch - DE (583 KB)
- Norwegian - NO (583 KB)
- Español - ES (583 KB)
- Swedish - SV (583 KB)
- Italian - IT (583 KB)
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Handling Instructions (2659 KB)
References
[1]. Asnis GM, et al. Levomilnacipran for the treatment of major depressive disorder: a review. Neuropsychiatr Dis Treat. 2015 Jan 9;11:125-35. [Content Brief]
[2]. Bundgaard C, et al. P-glycoprotein differentially affects escitalopram, levomilnacipran, vilazodone and vortioxetine transport at the mouse blood-brain barrier in vivo. Neuropharmacology. 2016 Apr;103:104-11. [Content Brief]
[3]. Wu Y, et al. Levomilnacipran Improves Lipopolysaccharide-Induced Dysregulation of Synaptic Plasticity and Depression-Like Behaviors via Activating BDNF/TrkB Mediated PI3K/Akt/mTOR Signaling Pathway. Mol Neurobiol. 2024 Jul;61(7):4102-4115. [Content Brief]
[4]. Auclair AL, et al. Levomilnacipran (F2695), a norepinephrine-preferring SNRI: profile in vitro and in models of depression and anxiety. Neuropharmacology. 2013 Jul;70:338-47. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.5359 mL | 17.6797 mL | 35.3594 mL | 88.3986 mL |
| 5 mM | 0.7072 mL | 3.5359 mL | 7.0719 mL | 17.6797 mL | |
| 10 mM | 0.3536 mL | 1.7680 mL | 3.5359 mL | 8.8399 mL | |
| 15 mM | 0.2357 mL | 1.1786 mL | 2.3573 mL | 5.8932 mL | |
| 20 mM | 0.1768 mL | 0.8840 mL | 1.7680 mL | 4.4199 mL | |
| 25 mM | 0.1414 mL | 0.7072 mL | 1.4144 mL | 3.5359 mL | |
| 30 mM | 0.1179 mL | 0.5893 mL | 1.1786 mL | 2.9466 mL | |
| 40 mM | 0.0884 mL | 0.4420 mL | 0.8840 mL | 2.2100 mL | |
| 50 mM | 0.0707 mL | 0.3536 mL | 0.7072 mL | 1.7680 mL | |
| 60 mM | 0.0589 mL | 0.2947 mL | 0.5893 mL | 1.4733 mL | |
| 80 mM | 0.0442 mL | 0.2210 mL | 0.4420 mL | 1.1050 mL | |
| 100 mM | 0.0354 mL | 0.1768 mL | 0.3536 mL | 0.8840 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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