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Cat. No.: HY-184907

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AI10-m15

AI10-m15 is a tyrosinase inhibitor, with IC₅₀ values of 0.019 μM (using L-DOPA (HY-N0304) as the substrate) and 0.02 μM (using L-Tyrosine (HY-N0473) as the substrate) against mushroom tyrosinase. AI10-m15 inhibits intracellular melanin production and reduces head pigmentation in zebrafish embryos. AI10-m15 can be used for the research of hyperpigmentation disorders.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₁₉H₂₀N₂O₄
분자량:340.37

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

AI10-m15 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

AI10-m15 (concentration gradient) exhibits improved cellular safety with a maximum nontoxic concentration of 100 μM in A375, B16F10, HEM, and HaCaT cells^[1].
AI10-m15 (12.5-100 μM) potently inhibits intracellular melanogenesis in B16F10 cells, with greater efficacy than kojic acid and β-arbutin across tested concentrations^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AI10-m15 (30-60 μM; exposure for 45 h) exhibits potent in vivo anti-melanogenic activity in zebrafish embryos, achieving a depigmentation rate of 20.93% at a concentration of 60 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

wild-type AB strain (6 hours postfertilization embryos)^[1]
Dosage:

30 μM; 60 μM
Administration:

exposure; 45 hours
Result:

Achieved a depigmentation efficacy of 20.93% at 60 μM, significantly reducing head melanophore signal intensity compared to the control group.
Showed measurable antimelanogenic activity with minimal toxicity at 30 μM.

Chemical Information

분자량 340.37
화학식 C₁₉H₂₀N₂O₄
SMILES

O=C(N1CCN(CC1)C2=CC=C(C=C2)O)/C=C/C3=C(C=C(C=C3)O)O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Pizzorno J, et al. Health Medicine. Integrative medicine (Encinitas, Calif.). 2022 Dec;21(6):8-14. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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