Cat. No.: HY-W015515

L-Citronellol

(Synonyms: (S)-3,7-Dimethyloct-6-en-1-ol)

고객리뷰

Based on 1 Customer Validation

L-Citronellol ((S)-3,7-Dimethyloct-6-en-1-ol) is a natural product with anti-allergic and neuroprotective effects. L-Citronellol inhibits mast cell activation and the release of inflammatory factors by inhibiting the ERK pathway. L-Citronellol inhibits BACE1/PSEN1 and AChE, reduces TNF-α expression and lipid peroxidation, demonstrating the potential of multi-target anti-Alzheimer's disease (AD).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.84%
CAS No.: 7540-51-4
화학식: C₁₀H₂₀O
분자량:156.27

보관:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

L-Citronellol Chemical Structure

CAS No.: 7540-51-4

사이즈

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재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
용액&용해도
- In Vitro
- In Vivo
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]^[2]

ERK

BACE1

All Beta-secretase Isoforms :

BACE1
BACE2

All Cholinesterase (ChE) Isoforms :

AChE
BChE

All TNF Receptor Isoforms :

All ERK Isoforms :

In Vitro

L-Citronellol (0-125 μM, 24 h) significantly enhances the survival rate of PC12 cells in an LPS (HY-D1056)-induced inflammatory environment in a dose-dependent manner^[1].
L-Citronellol (0-25 μM, 48 h) significantly reduces AChE activity and MDA levels, decreases TNF-α and increases BDNF mRNA expression in PC12 cells^[1].
L-Citronellol (0-500 μM, 1 h) inhibits the degranulation of cultured mast cells (CMCs)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[1]

Cell Line:

PC12 cells
Concentration:

0, 5 and 25 μM
Incubation Time:

48 h
Result:

Significantly inhibited TNF-α and promotes the increase in BDNF expression.

Chemical Information

CAS No. 7540-51-4
Appearance Liquid (Density: 0.845±0.06 g/cm³)
분자량 156.27
화학식 C₁₀H₂₀O
Color Colorless to light yellow
SMILES

C/C(C)=C\CC[C@H](C)CCO
Synonyms

(S)-3,7-Dimethyloct-6-en-1-ol
Structure Classification
- Terpenoids
- Other Monoterpenes
Initial Source
선적

Room temperature in continental US; may vary elsewhere.

보관

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 200 mg/mL (1279.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.3992 mL

31.9959 mL

63.9918 mL

5 mM

1.2798 mL

6.3992 mL

12.7984 mL

10 mM

0.6399 mL

3.1996 mL

6.3992 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 5 mg/mL (32.00 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 5 mg/mL (32.00 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 5 mg/mL (32.00 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhou J, et al. Natural compounds for Alzheimer's prevention and treatment: Integrating SELFormer-based computational screening with experimental validation. Comput Biol Med. 2025 Feb;185:109523. [Content Brief]

[2]. Kobayashi Y, et al. Inhibitory effects of geranium essential oil and its major component, citronellol, on degranulation and cytokine production by mast cells. Biosci Biotechnol Biochem. 2016 Jun;80(6):1172-8. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	6.3992 mL	31.9959 mL	63.9918 mL	159.9795 mL
	5 mM	1.2798 mL	6.3992 mL	12.7984 mL	31.9959 mL
	10 mM	0.6399 mL	3.1996 mL	6.3992 mL	15.9980 mL
	15 mM	0.4266 mL	2.1331 mL	4.2661 mL	10.6653 mL
	20 mM	0.3200 mL	1.5998 mL	3.1996 mL	7.9990 mL
	25 mM	0.2560 mL	1.2798 mL	2.5597 mL	6.3992 mL
	30 mM	0.2133 mL	1.0665 mL	2.1331 mL	5.3327 mL
	40 mM	0.1600 mL	0.7999 mL	1.5998 mL	3.9995 mL
	50 mM	0.1280 mL	0.6399 mL	1.2798 mL	3.1996 mL
	60 mM	0.1067 mL	0.5333 mL	1.0665 mL	2.6663 mL
	80 mM	0.0800 mL	0.3999 mL	0.7999 mL	1.9997 mL
	100 mM	0.0640 mL	0.3200 mL	0.6399 mL	1.5998 mL

Keywords

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L-Citronellol

Apoptosis Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

MAPK Compound Library

Neuronal Signaling Compound Library

Stem Cell Signaling Compound Library

Natural Product Library

Anti-Aging Compound Library

Differentiation Inducing Compound Library

Reprogramming Compound Library

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Ferroptosis Compound Library

Medicine Food Homology Compound Library

Terpenoids Library

Glutamine Metabolism Compound Library

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Anti-Alzheimer's Disease Compound Library

Neuroprotective Compound Library

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Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Antidepressant Compound Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

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Human Metabolite Library

Anti-Prostate Cancer Compound Library

Anti-Pulmonary Fibrosis Compound Library

Cancer Stem Cells Compound Library

Pain-Related Compound Library

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Protease Inhibitor Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Autoimmune Disease Compound Library

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MCE Bioactive Compound Library

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Natural Product Diversity Scaffold Library

Environmental Pollutant Compound Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

All Beta-secretase Isoforms

All Cholinesterase (ChE) Isoforms

All TNF Receptor Isoforms

All ERK Isoforms

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

L-Citronellol Related Classifications

HY-W015515 Related Classifications