MMP-13-IN-1
MMP-13-IN-1 is a potent and selective inhibitor of MMP-13 with a IC50 value of 16 nM. MMP-13-in-1 can be used for atherosclerosis research.
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- CAS No.: 2925249-49-4
- 화학식: C19H16F3N3O3
- 분자량:391.34
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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MMP13 16 nM (IC50) |
. MMP-13-IN-1 (compound 5j) (2.5 mg/kg; i.v., 15 min before the use of the radiotracer) displays the highest overall uptake and the greatest colocalization to ORO-positive regions[1]..
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ApoE−/− mice models[1]
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Dosage:2.5 mg/kg
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Administration:Intravenous injection (i.v.); intravenously administered 15 min prior to the radiotracer
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Result:Blood radioactivity continued to decrease between 30 and 60 min and stabilized thereafter.
Displayed a significant reduction in liver uptake.
Relatively low levels of radioactivity were observed in all other measured organs except for the pancreas and spleen.
Resulted in a 23% decrease in aortic plaque uptake , indicating an extent of saturable binding.
Chemical Information
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CAS No. 2925249-49-4
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분자량 391.34
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화학식 C19H16F3N3O3
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SMILES
FC(C(C)=C1)=CC=C1CNC(C2=NC3=C(C(N2)=O)C(OCCF)=C(C=C3)F)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MMP-13-IN-1 Related Classifications
HY-154868 Related Classifications
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