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Cat. No.: HY-W709448

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Oxaprozin-d10

(Synonyms: Oxaprozinum-d₁₀; Wy21743-d₁₀)

Oxaprozin-d₁₀ (Oxaprozinum-d₁₀; Wy21743-d₁₀) is the deuterium labeled Oxaprozin (HY-B0808). Oxaprozin is an orally active and potent COX inhibitor, with IC₅₀ values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB. Oxaprozin induces cell apoptosis. Oxaprozin shows anti-inflammatory activity. Oxaprozin-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₁₈H₅D₁₀NO₃
분자량:303.38

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (247 KB)

Oxaprozin-d10 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- 신청
Chemical Information
순도&문서
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Akt Isoforms :

All COX Isoforms :

All NF-κB Isoforms :

All IKK Isoforms :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

신청

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled Cas 21256-18-8
분자량 303.38
화학식 C₁₈H₅D₁₀NO₃
SMILES

[2H]C1=C(C([2H])=C(C([2H])=C1C2=C(OC(CCC(O)=O)=N2)C3=C(C([2H])=C(C([2H])=C3[2H])[2H])[2H])[2H])[2H]
Synonyms

Oxaprozinum-d₁₀; Wy21743-d₁₀
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.