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Cat. No.: HY-N21841

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Stypodiol

Stypodiol is an orally active sesquiterpenoid that can be isolated from Stypopodium flabelliforme. Stypodiol exhibits anticancer, gastric mucosal protective, and weak antibacterial activities. Stypodiol is used in research related to colon adenocarcinoma, neuroblastoma, basophilic leukemia, macrophage carcinoma, and gastric mucosal injury.

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CAS No.: 71106-25-7
화학식: C₂₇H₄₀O₄
분자량:428.60

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Stypodiol Chemical Structure

CAS No.: 71106-25-7

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Endogenous Metabolite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
AGS	IC₅₀	153 μM	Cytotoxicity against human epithelial gastric AGS cells assessed as reduction in cell viability incubated for 48 h by MTT assay. Cytotoxicity against human epithelial gastric AGS cells assessed as reduction in cell viability incubated for 48 h by MTT assay.	25830679
Fibroblast	IC₅₀	215 μM	Cytotoxicity against human fibroblasts assessed as reduction in cell viability incubated for 48 h by MTT assay. Cytotoxicity against human fibroblasts assessed as reduction in cell viability incubated for 48 h by MTT assay.	25830679

In Vitro

Stypodiol (12.5-50 μM; 48 h) selectively and concentration-dependently inhibits the proliferation of the RAW.267, SH-SY5Y, Caco-2, and RBL-2H3 cancer cell lines, exhibits very low activity against the non-cancerous V79 cell line, and achieves near-complete inhibition of SH-SY5Y cells at a concentration of 50 μM^[1].
Stypodiol (up to 500 μM; 48 h) inhibits the viability of human gastric epithelial AGS cells and fibroblasts, with IC₅₀ values of 153 μM and 215 μM, respectively^[2].
Stypodiol (24 h) exhibits weak antibacterial activity, with an MIC of 206 μg/mL against E. faecalis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

RAW.267, SH-SY5Y, Caco-2, RBL-2H3, V79
Concentration:

12.5, 25, 50 µM
Incubation Time:

48 h
Result:

Showed a concentration-dependent inhibitory effect on the proliferation of all tested cancer cell lines, but exhibited less toxicity to the non-cancer cell line V79, demonstrating selectivity.

In Vivo

Stypodiol (40 mg/kg; p.o.; single administration; 50 min pre-treatment prior to 1 h of HCl/EtOH induction) exerts a gastroprotective effect against gastric mucosal injury in a mouse model of HCl/EtOH-induced gastric mucosal damage^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Swiss albino mice (30 g)^[2]
Dosage:

40 mg/kg
Administration:

p.o.; single dose; 50 min pre-treatment prior to 1 h of HCl/EtOH induction
Result:

Reduced the appearance of gastric mucosal lesions.
Decreased the gastric lesion index by 69%.

Chemical Information

CAS No. 71106-25-7
분자량 428.60
화학식 C₂₇H₄₀O₄
SMILES

C[C@]12[C@@]3([C@H](CC[C@]1([H])[C@@]4([C@@](C(C)([C@H](CC4)O)C)([H])CC2)C)C)CC5=C(O)C(O)=CC(C)=C5O3
Structure Classification
- Terpenoids
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Pereira DM, et al. Anti-proliferative activity of meroditerpenoids isolated from the brown alga Stypopodium flabelliforme against several cancer cell lines. Marine drugs. 2011;9(5):852-862.

[2]. Areche C, et al. Seco-taondiol, an unusual meroterpenoid from the Chilean seaweed Stypopodium flabelliforme and its gastroprotective effect in mouse model. Marine drugs. 2015 Mar 30;13(4):1726-38.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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