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Cat. No.: HY-187623

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U 92163

U 92163 is an HIV-2 protease inhibitor. It is a synthetic peptidomimetic transition-state analog. U 92163 binds in an extended conformation along the length of the enzyme's binding cleft, and forms hydrogen bonds with the catalytic aspartate pair and other protease residues to block enzyme activity. U 92163 can be used in research on acquired immunodeficiency syndrome (AIDS).

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CAS No.: 149607-21-6
화학식: C₃₄H₅₁N₅O₅
분자량:609.81

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

U 92163 Chemical Structure

CAS No.: 149607-21-6

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

U 92163 plays a role in the crystalline HIV-2 protease/inhibitor complex by occupying the substrate-binding pocket of the protease binding cleft, forming a hydrogen bond network with the catalytic site Asp25/Asp125 and side chain residues, and inducing protein conformational changes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 149607-21-6
분자량 609.81
화학식 C₃₄H₅₁N₅O₅
SMILES

C(N[C@H](C(N[C@@H](CC1CCCCC1)[C@H](C[C@H](C(NCC(C)(C)C)=O)[C@H](C)C)O)=O)CC(N)=O)(=O)C2=NC3=C(C=C2)C=CC=C3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Mulichak AM, et al. The crystallographic structure of the protease from human immunodeficiency virus type 2 with two synthetic peptidic transition state analog inhibitors. The Journal of biological chemistry. 1993 Jun 25;268(18):13103-9.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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