L-2-Aminooxy-3-phenylpropanoic acid
Based on 1 Customer Validation
L-2-Aminooxy-3-phenylpropanoic acid (L-α-aminooxy-β-phenylpropionic acid; AOPP) is an inhibitor of L-phenylalanine ammonia-lyase (PAL). L-2-Aminooxy-3-phenylpropanoic acid inhibits lignification without reducing the number of tracheary elements formed.
For research use only. We do not sell to patients.
- Purity : 99.8%
- CAS No.: 42990-62-5
- Formula: C9H11NO3
- Molecular Weight:181.19
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
L-2-Aminooxy-3-phenylpropanoic acid (Compound AOPP) (10 μM) reduces the proportion of lignified tracheary elements and the content of lignin in the lignified tracheary elements as well as causing an increase in the activities of ionically and tightly bound peroxidase in mesophyll cells of Zinnia[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 42990-62-5
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Appearance Solid
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Molecular Weight 181.19
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Formula C9H11NO3
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Color White to off-white
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SMILES
OC([C@@H](ON)CC1=CC=CC=C1)=O
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Synonyms
L-α-aminooxy-β-phenylpropionic acid; AOPP
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 250 mg/mL (1379.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (11.48 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (11.48 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.5190 mL | 27.5952 mL | 55.1904 mL | 137.9760 mL |
| 5 mM | 1.1038 mL | 5.5190 mL | 11.0381 mL | 27.5952 mL | |
| 10 mM | 0.5519 mL | 2.7595 mL | 5.5190 mL | 13.7976 mL | |
| 15 mM | 0.3679 mL | 1.8397 mL | 3.6794 mL | 9.1984 mL | |
| 20 mM | 0.2760 mL | 1.3798 mL | 2.7595 mL | 6.8988 mL | |
| 25 mM | 0.2208 mL | 1.1038 mL | 2.2076 mL | 5.5190 mL | |
| 30 mM | 0.1840 mL | 0.9198 mL | 1.8397 mL | 4.5992 mL | |
| 40 mM | 0.1380 mL | 0.6899 mL | 1.3798 mL | 3.4494 mL | |
| 50 mM | 0.1104 mL | 0.5519 mL | 1.1038 mL | 2.7595 mL | |
| 60 mM | 0.0920 mL | 0.4599 mL | 0.9198 mL | 2.2996 mL | |
| 80 mM | 0.0690 mL | 0.3449 mL | 0.6899 mL | 1.7247 mL | |
| 100 mM | 0.0552 mL | 0.2760 mL | 0.5519 mL | 1.3798 mL |
L-2-Aminooxy-3-phenylpropanoic acid Related Classifications
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