Lacto-N-neodifucohexaose II
Lacto-N-neodifucohexaose II (LNnDFH II) is a neutral difucosylated human milk oligosaccharide (HMO). Lacto-N-neodifucohexaose II is a characteristic HMO associated with the non-secretor phenotype in human milk, and its concentration pattern is positively correlated with the colonization of B. breve in the infant gut.
For research use only. We do not sell to patients.
- CAS No.: 2583908-45-4
- Formula: C44H76N4O29
- Molecular Weight:1125.08
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
Lacto-N-neodifucohexaose II contains fucose residues on both its LacNAc and Lac moieties, and is synthesized enzymatically using Helicobacter pylori α1-3-fucosyltransferase (Hp3FT) with a high GDP-Fuc to acceptor ratio[1].
The median concentration of Lacto-N-neodifucohexaose II in mature breast milk from non-secretor Chinese mothers (90.8 mg/L) is significantly higher than that in mature breast milk from secretor mothers (22.4 mg/L)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2583908-45-4
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Molecular Weight 1125.08
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Formula C44H76N4O29
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SMILES
OC[C@@H]([C@H]([C@H]([C@@H]1O)O)O)O[C@@H]1O[C@@H]([C@@H](O[C@@H]([C@H]2NC(C)=O)O[C@H]3[C@@H]([C@H](O[C@H]([C@H]3O)CO)O[C@@H]4[C@H]([C@@H]([C@H](O[C@H]4CO)OCCCCCCN=[N+]=[N-])O)O[C@@H]5[C@@H]([C@H]([C@H]([C@H](O5)C)O)O)O)O)CO)[C@H]2O[C@@H]6[C@@H]([C@H]([C@H]([C@H](O6)C)O)O)O
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Synonyms
LNnDFH II
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Structure Classification
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Initial Source
Helicobacter pylori
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Bai J, et al. Biochemical characterization of Helicobacter pylori α1-3-fucosyltransferase and its application in the synthesis of fucosylated human milk oligosaccharides. Carbohydrate research. 2019 Jul 01;480:1-6. [Content Brief]
[2]. Mao S, et al. Patterns of Human Milk Oligosaccharides in Mature Milk Are Associated with Certain Gut Microbiota in Infants. Nutrients. 2024 Apr 25;16(9):1287. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lacto-N-neodifucohexaose II Related Classifications
HY-N11454 Related Classifications
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Keywords
- Lacto-N-neodifucohexaose II
- 2583908-45-4
- LNnDFH II
- Endogenous Metabolite
- LacNAc
- breastfed infants
- Lac moieties
- lacto-N-neotetraose
- human milk oligosaccharide
- secretor mothers
- Bifidobacterium breve
- non-secretor Chinese mothers
- Helicobacter pylori α1-3-fucosyltransferase
- mature breast milk
- Inhibitor
- inhibitor
- inhibit