Isotope-Labeled Secosteroids

Doxercalciferol-d₆ (1.alpha.-Hydroxyvitamin D2-d₆) is deuterium labeled Doxercalciferol. Doxercalciferol is a Vitamin D2 analog, acts as an activator of Vitamin D receptor, and prevent renal disease.

Ercalcitriol-d₃ (1α,25-Dihydroxy Vitamin D2-d₃) is the deuterium labeled Ercalcitriol (HY-32350). Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases.

3-Epi-25-hydroxyvitamin D3-¹³C₅ is the ¹³C labeled 3-Epi-25-hydroxyvitamin D3.

3-Epi-25-Hydroxyvitamin D3-d₃ is the deuterium labeled 3-Epi-25-Hydroxyvitamin D3.

Calcitriol-¹³C₃ is the ¹³C-labeled Calcitriol. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.

7-Keto Cholesterol-d₇ is the deuterium labeled 7-Keto Cholesterol.

Secalciferol-d₆ is the deuterium labeled Secalciferol. Secalciferol is a metabolite of Vitamin D, a possibly anti-inflammatory steroid which is involved in bone ossification.