MAL-di-EG-Val-Cit-PAB-MMAF

Cat. No.: HY-128711 Purity: 95.99%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

MAL-di-EG-Val-Cit-PAB-MMAF consists the ADCs linker (MAL-di-EG-Val-Cit-PAB) and potent tubulin polymerization blocker (MMAF, Monomethyl auristatin F).

For research use only. We do not sell to patients.

MAL-di-EG-Val-Cit-PAB-MMAF Chemical Structure

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 Customer Validation

Other Forms of MAL-di-EG-Val-Cit-PAB-MMAF:

MAL-di-EG-Val-Cit-PAB-MMAE In-stock

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•Related Small Molecules:

•Related Proteins:

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

View All Isoforms

Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

Biological Activity
Purity & Documentation
References
Customer Review

Description

MAL-di-EG-Val-Cit-PAB-MMAF consists the ADCs linker (MAL-di-EG-Val-Cit-PAB) and potent tubulin polymerization blocker (MMAF, Monomethyl auristatin F)^[1].

IC₅₀ & Target

Auristatin

Molecular Weight

1447.71

Formula

C₇₂H₁₁₀N₁₂O₁₉

Appearance

Solid

Color

White to off-white

SMILES

CC(C)[C@@H](C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H]([C@@H](C)CC)[C@@H](CC(N2[C@@H](CCC2)[C@@H]([C@@H](C)C(N[C@H](C(O)=O)CC3=CC=CC=C3)=O)OC)=O)OC)=O)=O)=O)C=C1)=O)=O)NC(CCOCCOCCNC(CCN4C(C=CC4=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility

In Vitro:

DMSO : 230 mg/mL (158.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.6907 mL	3.4537 mL	6.9075 mL
5 mM	0.1381 mL	0.6907 mL	1.3815 mL
10 mM	0.0691 mL	0.3454 mL	0.6907 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.56%

Select Batch:

Data Sheet (266 KB) SDS (252 KB)

COA (247 KB) HNMR (161 KB) LCMS (111 KB)

Handling Instructions (2659 KB)

References

[1]. McCombs JR, et al. Antibody drug conjugates: design and selection of linker, payload and conjugation chemistry. AAPS J. 2015 Mar;17(2):339-51. [Content Brief]

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.6907 mL	3.4537 mL	6.9075 mL	17.2687 mL
	5 mM	0.1381 mL	0.6907 mL	1.3815 mL	3.4537 mL
	10 mM	0.0691 mL	0.3454 mL	0.6907 mL	1.7269 mL
	15 mM	0.0460 mL	0.2302 mL	0.4605 mL	1.1512 mL
	20 mM	0.0345 mL	0.1727 mL	0.3454 mL	0.8634 mL
	25 mM	0.0276 mL	0.1381 mL	0.2763 mL	0.6907 mL
	30 mM	0.0230 mL	0.1151 mL	0.2302 mL	0.5756 mL
	40 mM	0.0173 mL	0.0863 mL	0.1727 mL	0.4317 mL
	50 mM	0.0138 mL	0.0691 mL	0.1381 mL	0.3454 mL
	60 mM	0.0115 mL	0.0576 mL	0.1151 mL	0.2878 mL
	80 mM	0.0086 mL	0.0432 mL	0.0863 mL	0.2159 mL
	100 mM	0.0069 mL	0.0345 mL	0.0691 mL	0.1727 mL