MAL-di-EG-Val-Cit-PAB-MMAF

Cat. No.: HY-128711 Purity: 98.02%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

MAL-di-EG-Val-Cit-PAB-MMAF consists the ADCs linker (MAL-di-EG-Val-Cit-PAB) and potent tubulin polymerization blocker (MMAF, Monomethyl auristatin F).

For research use only. We do not sell to patients.

MAL-di-EG-Val-Cit-PAB-MMAF Chemical Structure

Size	Price	Stock	Quantity
5 mg	USD 860	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1380	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of MAL-di-EG-Val-Cit-PAB-MMAF:

MAL-di-EG-Val-Cit-PAB-MMAE In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

MAL-di-EG-Val-Cit-PAB-MMAF consists the ADCs linker (MAL-di-EG-Val-Cit-PAB) and potent tubulin polymerization blocker (MMAF, Monomethyl auristatin F)^[1].

IC₅₀ & Target

Auristatin

Molecular Weight

1476.75

Formula

C₇₃H₁₁₃N₁₃O₁₉

Appearance

Solid

Color

White to off-white

SMILES

CN([C@H](C(N[C@H](C(N([C@H]([C@@H](CC(N1CCC[C@@]1([H])[C@H](OC)[C@@H](C)C(N[C@@H](CC2=CC=CC=C2)C(O)=O)=O)=O)OC)[C@H](CC)C)C)=O)C(C)C)=O)C(C)C)N(C)C(OCC3=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCNC(CCN4C(C=CC4=O)=O)=O)=O)=O)=O)C=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility

In Vitro:

DMSO : 230 mg/mL (155.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.6772 mL	3.3858 mL	6.7716 mL
5 mM	0.1354 mL	0.6772 mL	1.3543 mL
10 mM	0.0677 mL	0.3386 mL	0.6772 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.56%

Select Batch:

Data Sheet (267 KB) SDS (251 KB)

COA (249 KB) HNMR (217 KB) LCMS (121 KB)

Handling Instructions (2659 KB)

References

[1]. McCombs JR, et al. Antibody drug conjugates: design and selection of linker, payload and conjugation chemistry. AAPS J. 2015 Mar;17(2):339-51. [Content Brief]

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.6772 mL	3.3858 mL	6.7716 mL	16.9291 mL
	5 mM	0.1354 mL	0.6772 mL	1.3543 mL	3.3858 mL
	10 mM	0.0677 mL	0.3386 mL	0.6772 mL	1.6929 mL
	15 mM	0.0451 mL	0.2257 mL	0.4514 mL	1.1286 mL
	20 mM	0.0339 mL	0.1693 mL	0.3386 mL	0.8465 mL
	25 mM	0.0271 mL	0.1354 mL	0.2709 mL	0.6772 mL
	30 mM	0.0226 mL	0.1129 mL	0.2257 mL	0.5643 mL
	40 mM	0.0169 mL	0.0846 mL	0.1693 mL	0.4232 mL
	50 mM	0.0135 mL	0.0677 mL	0.1354 mL	0.3386 mL
	60 mM	0.0113 mL	0.0564 mL	0.1129 mL	0.2822 mL
	80 mM	0.0085 mL	0.0423 mL	0.0846 mL	0.2116 mL
	100 mM	0.0068 mL	0.0339 mL	0.0677 mL	0.1693 mL