MDM2/4-p53-IN-2
MDM2/4-p53-IN-2 (2q) is a potent dual MDM2/ MDM4 inhibitor and p53 activator with the IC50 values of 70.7 nM for MDM2- p53 and 81.4 nM for MDM4-p53 complexes. MDM2/4-p53-IN-2 regulates the cell cycle, induces cell apoptosis and has anticancer activity.
For research use only. We do not sell to patients.
- CAS No.: 3037300-49-2
- Formula: C25H17Cl3FN3O3
- Molecular Weight:532.78
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MDM2/4-p53-IN-2 (2q) (1-100 μM, 96 h) can inhibit the proliferation of cancer cells and induce cell apoptosis by targeting the G0/G1 cell cycle in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human cancer cell lines HCT116, SJSA-1, MCF-7, LNCaP, human embryonic kidney epithelial cell line HEK 293T
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Concentration:1-100 μM
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Incubation Time:48 hours
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Result:Showed anti-proliferative activity of HCT116 with an IC50 value of 18.0 μM.
Showed well inhibition of cell viability against SJSA-1, MCF-7, LNCaP cells, all below 40%.
Reduced cell viability of HEK 293T cells by 24%.
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Cell Line:SJSA-1 cell lines
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Concentration:15 and 22.5 μM
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Incubation Time:96 hours
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Result:Increased LDH release by 1.3-fold and 1.6-fold at concentrations of 15 μM and 22.5 μM, respectively.
Caused a decrease in SJSA-1 cells, a significant decrease in cell growth and an increase in the number of early and late stage apoptotic cells at 22.5 μM.
Induced a significant accumulation of G0/G1 phase cells with a percentage of 67.5% at 15 μM and 82.2% at 22.5 μM, while reducing the percentage of S and G2/M phase cells.
Chemical Information
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CAS No. 3037300-49-2
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Molecular Weight 532.78
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Formula C25H17Cl3FN3O3
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SMILES
O=C(OCC)C([C@@H]1C2=CC=CC(Cl)=C2F)=NN([C@]13C(NC4=C3C=CC(Cl)=C4)=O)C5=CC=C(C=C5)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MDM2/4-p53-IN-2 Related Classifications
HY-151170 Related Classifications
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