mDPR-Val-Cit-PAB-MMAE TFA

Cat. No.: HY-19813A Purity: 99.51%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

mDPR-Val-Cit-PAB-MMAE TFA is a drug-linker conjugate for ADC (Drug-Linker Conjugates for ADC), consisting of a tubulin polymerization inhibitor MMAE (HY-15162) and an ADC linker (peptide Val-Cit- PAB) composition^{[1]^.}

For research use only. We do not sell to patients.

mDPR-Val-Cit-PAB-MMAE TFA Chemical Structure

CAS No. : 2185872-76-6

Size	Price	Stock	Quantity
1 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1050	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

1403.58

Formula

C₆₇H₁₀₁F₃N₁₂O₁₇

CAS No.

2185872-76-6

Appearance

Solid

Color

White to off-white

SMILES

CC[C@H](C)[C@@H]([C@@H](CC(N1[C@@H](CCC1)[C@@H]([C@@H](C)C(N[C@H](C)[C@@H](O)C2=CC=CC=C2)=O)OC)=O)OC)N(C([C@H](C(C)C)NC([C@H](C(C)C)N(C(OCC3=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC([C@@H](N4C(C=CC4=O)=O)CN)=O)=O)=O)C=C3)=O)C)=O)=O)C.O=C(O)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (71.25 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7125 mL	3.5623 mL	7.1246 mL
5 mM	0.1425 mL	0.7125 mL	1.4249 mL
10 mM	0.0712 mL	0.3562 mL	0.7125 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.51%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (252 KB) HNMR (261 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Moquist, et al. Preparation of drug conjugates of IgG1 antibodies with self-stabilizing linkers having improved physiochemical properties for treating cancers and autoimmune diseases. World Intellectual Property Organization, WO2018031690 A1. 2018-02-15.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.7125 mL	3.5623 mL	7.1246 mL	17.8116 mL
	5 mM	0.1425 mL	0.7125 mL	1.4249 mL	3.5623 mL
	10 mM	0.0712 mL	0.3562 mL	0.7125 mL	1.7812 mL
	15 mM	0.0475 mL	0.2375 mL	0.4750 mL	1.1874 mL
	20 mM	0.0356 mL	0.1781 mL	0.3562 mL	0.8906 mL
	25 mM	0.0285 mL	0.1425 mL	0.2850 mL	0.7125 mL
	30 mM	0.0237 mL	0.1187 mL	0.2375 mL	0.5937 mL
	40 mM	0.0178 mL	0.0891 mL	0.1781 mL	0.4453 mL
	50 mM	0.0142 mL	0.0712 mL	0.1425 mL	0.3562 mL
	60 mM	0.0119 mL	0.0594 mL	0.1187 mL	0.2969 mL