2. Anti-infection
  3. Beta-lactamase
  4. Metallo-β-lactamase-IN-15

Metallo-β-lactamase-IN-15 (Compound ±13) is a potent MBL inhibitor, the IC50 values for NDM-1、IMP-1 and VIM-2 were 0.29 μM, 0.088 μM and 0.063 μM, respectively.

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Metallo-β-lactamase-IN-15 Chemical Structure

Metallo-β-lactamase-IN-15 Chemical Structure

CAS No. : 1804934-57-3

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Metallo-β-lactamase-IN-15 Related Antibodies

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Description

Metallo-β-lactamase-IN-15 (Compound ±13) is a potent MBL inhibitor, the IC50 values for NDM-1、IMP-1 and VIM-2 were 0.29 μM, 0.088 μM and 0.063 μM, respectively[1].

IC50 & Target

NDM-1

0.29 μM (IC50)

VIM-2

0.063 μM (IC50)

IMP-1

0.088 μM (IC50)

In Vitro

Metallo-β-lactamase-IN-15 (Compound ±13) (50 ug/mL; 100 ug/mL) was not toxic to L929 cells[1].
Metallo-β-lactamase-IN-15 has good bioavailability and plasma stability[1].
Metallo-β-lactamase-IN-15 (100 μg/mL;1h, 3h, 5h) growth activity of NDM-1-expressing E.coli DH5α strain, Metallo-β-lactamase-IN-15 restored imipenem activity in vitro[1].
Metallo-β-lactamase-IN-15 (100 μg/mL) decreased the minimum inhibitory concentration of meropenem in clinical E.coli DH5α strain[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Metallo-β-lactamase-IN-15 Related Antibodies

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Cell Viability Assay

Cell Line: E.coli DH5α cells
Concentration: 100 ug/mL
Incubation Time: 1h, 3h, 5h
Result: Metallo-β-lactamase-IN-15 restored imipenem activity[1].

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Cell Line:
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Molecular Weight

241.40

Formula

C10H11NS3
CAS No.
SMILES

SC[C@H]1SC[C@]2([H])SC3=CC=CC=C3N21
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Metallo-β-lactamase-IN-15 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Metallo-β-lactamase-IN-151804934-57-3Beta-lactamaseβ-lactamaseAntimicrobial resistanceMBL inhibitorsBBH inhibitors.Inhibitorinhibitorinhibit

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