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Cat. No.: HY-161310

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Metallo-β-lactamase-IN-15

Metallo-β-lactamase-IN-15 (Compound ±13) is a potent MBL inhibitor, the IC₅₀ values for NDM-1、IMP-1 and VIM-2 were 0.29 μM, 0.088 μM and 0.063 μM, respectively.

For research use only. We do not sell to patients.

CAS No.: 1804934-57-3
Formula: C₁₀H₁₁NS₃
Molecular Weight:241.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Metallo-β-lactamase-IN-15 Chemical Structure

CAS No.: 1804934-57-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Metallo-β-lactamase-IN-15 (Compound ±13) is a potent MBL inhibitor, the IC₅₀ values for NDM-1、IMP-1 and VIM-2 were 0.29 μM, 0.088 μM and 0.063 μM, respectively^[1].

IC₅₀ & Target

NDM-1

0.29 μM (IC₅₀)

VIM-2

0.063 μM (IC₅₀)

IMP-1

0.088 μM (IC₅₀)

All Beta-lactamase Isoforms :

In Vitro

Metallo-β-lactamase-IN-15 (Compound ±13) (50 ug/mL; 100 ug/mL) was not toxic to L929 cells^[1].
Metallo-β-lactamase-IN-15 has good bioavailability and plasma stability^[1].
Metallo-β-lactamase-IN-15 (100 μg/mL;1h, 3h, 5h) growth activity of NDM-1-expressing E.coli DH5α strain, Metallo-β-lactamase-IN-15 restored imipenem activity in vitro^[1].
Metallo-β-lactamase-IN-15 (100 μg/mL) decreased the minimum inhibitory concentration of meropenem in clinical E.coli DH5α strain^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Cell Viability Assay

Cell Line:

E.coli DH5α cells
Concentration:

100 ug/mL
Incubation Time:

1h, 3h, 5h
Result:

Metallo-β-lactamase-IN-15 restored imipenem activity^[1].

Cell Line:
Concentration:
Incubation Time:
Result:

Cell Line:
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Chemical Information

CAS No. 1804934-57-3
Molecular Weight 241.40
Formula C₁₀H₁₁NS₃
SMILES

SC[C@H]1SC[C@]2([H])SC3=CC=CC=C3N21
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Villamil, Valentina et al. “Rational Design of Benzobisheterocycle Metallo-β-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes.” Journal of medicinal chemistry, 19 Feb. 2024. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Metallo-β-lactamase-IN-15

All Beta-lactamase Isoforms