(-)-11,13-Dehydroeriolin
(-)-11,13-Dehydroeriolin (compound 9), a sesquiterpene lactone, is a nature product that could be isolated from Carpesium abrotanoides L. (-)-11,13-Dehydroeriolin has antiproliferative active. (-)-11,13-Dehydroeriolin can be used in research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 87441-73-4
- Formula: C15H20O4
- Molecular Weight:264.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
2 μM
Compound: 3
|
Cytotoxicity against human A549 cells after 72 hrs by CCK8 assay
Cytotoxicity against human A549 cells after 72 hrs by CCK8 assay
|
[PMID: 26316467] |
| DU-145 | IC50 |
0.38 μM
Compound: 3
|
Cytotoxicity against human DU145 cells after 72 hrs by CCK8 assay
Cytotoxicity against human DU145 cells after 72 hrs by CCK8 assay
|
[PMID: 26316467] |
| HeLa | IC50 |
1 μM
Compound: 3
|
Cytotoxicity against human HeLa cells after 72 hrs by CCK8 assay
Cytotoxicity against human HeLa cells after 72 hrs by CCK8 assay
|
[PMID: 26316467] |
| HL-60 | IC50 |
0.18 μM
Compound: 3
|
Cytotoxicity against human HL60 cells after 72 hrs by CCK8 assay
Cytotoxicity against human HL60 cells after 72 hrs by CCK8 assay
|
[PMID: 26316467] |
| K562 | IC50 |
1.7 μM
Compound: 3
|
Cytotoxicity against human K562 cells after 72 hrs by CCK8 assay
Cytotoxicity against human K562 cells after 72 hrs by CCK8 assay
|
[PMID: 26316467] |
| MCF7 | IC50 |
4.1 μM
Compound: 3
|
Cytotoxicity against human MCF7 cells after 72 hrs by CCK8 assay
Cytotoxicity against human MCF7 cells after 72 hrs by CCK8 assay
|
[PMID: 26316467] |
| MDCK | IC50 |
10.8 μM
Compound: 3
|
Antiviral activity against Influenza A virus H1N1 infected in MDCK cells assessed as protection against virus-induced cytopathic effect after 48 hrs by crystal violet staining
Antiviral activity against Influenza A virus H1N1 infected in MDCK cells assessed as protection against virus-induced cytopathic effect after 48 hrs by crystal violet staining
|
[PMID: 26316467] |
| MDCK | IC50 |
11.6 μM
Compound: 3
|
Antiviral activity against Influenza A virus H3N2 infected in MDCK cells assessed as protection against virus-induced cytopathic effect after 48 hrs by crystal violet staining
Antiviral activity against Influenza A virus H3N2 infected in MDCK cells assessed as protection against virus-induced cytopathic effect after 48 hrs by crystal violet staining
|
[PMID: 26316467] |
| MOLT-4 | IC50 |
1.2 μM
Compound: 3
|
Cytotoxicity against human MOLT4 cells after 72 hrs by CCK8 assay
Cytotoxicity against human MOLT4 cells after 72 hrs by CCK8 assay
|
[PMID: 26316467] |
| NCI-H1975 | IC50 |
5.4 μM
Compound: 3
|
Cytotoxicity against human NCI-H1975 cells after 72 hrs by CCK8 assay
Cytotoxicity against human NCI-H1975 cells after 72 hrs by CCK8 assay
|
[PMID: 26316467] |
| SGC-7901 | IC50 |
6.4 μM
Compound: 3
|
Cytotoxicity against human SGC7901 cells after 72 hrs by CCK8 assay
Cytotoxicity against human SGC7901 cells after 72 hrs by CCK8 assay
|
[PMID: 26316467] |
| U-937 | IC50 |
0.21 μM
Compound: 3
|
Cytotoxicity against human U937 cells after 72 hrs by CCK8 assay
Cytotoxicity against human U937 cells after 72 hrs by CCK8 assay
|
[PMID: 26316467] |
Chemical Information
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CAS No. 87441-73-4
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Molecular Weight 264.32
-
Formula C15H20O4
-
SMILES
C[C@@]1(C[C@@](OC2=O)([H])[C@](C2=C)([H])C[C@]3([H])[C@@]4(O3)C)[C@](CC4)([H])O1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)