Mu opioid receptor antagonist 7
Mu opioid receptor antagonist 7 (compound 24) is a potent and CNS permeable antagonist of µOR (µ-opioid receptor), with an IC50 of 29 ± 3.0 nM. Mu opioid receptor antagonist 7 can be used for the research of pain and opioid use disorder.
For research use only. We do not sell to patients.
- CAS No.: 2378397-30-7
- Formula: C22H27ClN2O2
- Molecular Weight:386.91
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Opioid Receptor Isoforms
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Biological Activity
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μ Opioid Receptor/MOR 29 ± 3.0 nM (IC50) |
Mu opioid receptor antagonist 7 (10 mg/kg, rat) can revert respiratory suppression induced by fentanyl, a higher efficacy µOR agonist[1].
Mu opioid receptor antagonist 7 (10 mg/kg, sc, rat) can achieve 70% receptor occupancy of the µOR thus demonstrating the high CNS permeability of this compound[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2378397-30-7
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Molecular Weight 386.91
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Formula C22H27ClN2O2
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SMILES
OC1=CC(Cl)=C(C[C@H](N(C)C)CNC([C@@H]2C[C@]2(C)C3=CC=CC=C3)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mu opioid receptor antagonist 7 Related Classifications
HY-155320 Related Classifications
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