Multi-Leu peptide (Synonyms: ML-peptide, Multi-Leucine (ML)-peptide)

Art. -Nr.: HY-P10422: Data Sheet Handling Instructions
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Technical Support

Multi-Leu peptide (ML-peptide) is a potent inhibitor of PACE4 (K_i=22 nM). Multi-Leu peptide can competitively bind to the active site of PACE4 by simulating the substrate sequence of PACE4, thereby inhibiting its catalytic activity. Multi-Leu peptide can be used to study the specific mechanism of PACE4 in the development of prostate cancer.

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Kundenspezifische Peptidsynthese

Multi-Leu peptide Chemische Struktur

CAS. Nr. : 1413058-07-7

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Other In-stock Forms of Multi-Leu peptide:

Multi-Leu peptide triacetate

Other Forms of Multi-Leu peptide:

Multi-Leu peptide triacetate In-stock

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität
Reinheit & Dokumentation
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Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	100 μM Compound: 1	Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay	[PMID: 30180568]
DU-145	IC₅₀	100 μM Compound: Ac-LLLLRVKR-NH2	Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23126600]
DU-145	IC₅₀	100 μM Compound: ML	Cytotoxicity against human DU145 cells after 72 hrs by MTT assay Cytotoxicity against human DU145 cells after 72 hrs by MTT assay	[PMID: 24350995]
DU-145	IC₅₀	25 μM Compound: 1	Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay	[PMID: 30501188]
LNCaP	IC₅₀	180 μM Compound: 1	Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay	[PMID: 30180568]
LNCaP	IC₅₀	180 μM Compound: Ac-LLLLRVKR-NH2	Cytotoxicity against human LNCAP cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human LNCAP cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23126600]
LNCaP	IC₅₀	180 μM Compound: ML	Cytotoxicity against human LNCAP cells after 72 hrs by MTT assay Cytotoxicity against human LNCAP cells after 72 hrs by MTT assay	[PMID: 24350995]
LNCaP	IC₅₀	45 μM Compound: 1	Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay	[PMID: 30501188]

Molekulargewicht

1051.37

Formel

C₄₉H₉₄N₁₆O₉

CAS. Nr.

1413058-07-7

Sequence

Ac-Leu-Leu-Leu-Leu-Arg-Val-Lys-Arg-NH2

Sequence Shortening

Ac-LLLLRVKR-NH2

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Łepek T, et al. Macrocyclization of a potent PACE4 inhibitor: Benefits and limitations[J]. European journal of cell biology, 2017, 96(5): 476-485. [Content Brief]

Multi-Leu peptide Related Classifications

Molaritätsrechner
Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Diese Gleichung wird häufig abgekürzt als: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Multi-Leu peptide1413058-07-7ML-peptide, Multi-Leucine (ML)-peptideAutophagyLeucinepeptidesinhibitorPACE4prostate cancerInhibitorinhibit

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Multi-Leu peptide (Synonyms: ML-peptide, Multi-Leucine (ML)-peptide)

Other Forms of Multi-Leu peptide:

Multi-Leu peptide Related Antibodies

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität

Reinheit & Dokumentation

Verweise

Kundenbewertung

Multi-Leu peptide Related Classifications

Molaritätsrechner

Verdünnungsrechner