381 Results for "

factor I

" in MedChemExpress (MCE) Product Catalog:
Products (381)

381 Results for "factor I" in MCE Product Catalog:

70
70 Publications Verification
Cat. No.: HY-16560
CAS No.: 7689-03-4
Synonyms: Campathecin; (S)-(+)-Camptothecin; CPT
Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM . Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells .
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27
27 Cited Publications
Cat. No.: HY-P7018
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGF1; Somatomedin-C; Insulin Like Growth factor 1; IGF1A; IGF-I; MGF; Insulin-Like Growth factor 1; Insulin-Like Growth factor IB; Insulin-Like Growth factor I; Insulin-Like Growth factor-I; IGFI; Alternative Protein IGF1; IGF; Somatomedin C; Insulin-Like
Species:  
Human
Source:  
E. coli
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22
22 Cited Publications
Cat. No.: HY-13012
CAS No.: 446859-33-2
Purity:  99.92%
Synonyms: E-616452; SJN 2511
Research Areas:  

Metabolic Disease

RepSox (E-616452) is a potent and selective transforming growth factor-beta receptor I/activin like kinase 5 (TGF-β-RI/ALK5) inhibitor. RepSox inhibits ALK5 autophosphorylation with an IC50 value of 4 nM. RepSox can be used for the research of obesity and associated metabolic diseases such as type 2 diabetes .
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12
12 Cited Publications
Cat. No.: HY-P7070
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGF1; Somatomedin-C; Insulin Like Growth factor 1; IGF1A; IGF-I; MGF; Insulin-Like Growth factor 1; Insulin-Like Growth factor IB; Insulin-Like Growth factor I; Insulin-Like Growth factor-I; IGFI; Alternative Protein IGF1; IGF; Somatomedin C; Insulin-Like
Species:  
Mouse
Source:  
E. coli
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9
9 Cited Publications
Cat. No.: HY-P2093
CAS No.: 1083433-49-1
Target:  

Insulin Receptor

Research Areas:  

Metabolic Disease

S961 is an high-affinity and selective insulin receptor (IR) antagonist with IC50s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively .
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9
9 Cited Publications
Cat. No.: HY-P2093B
Target:  

Insulin Receptor

Research Areas:  

Metabolic Disease

S961 acetate is an high-affinity and selective insulin receptor (IR) antagonist with IC50s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively .
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9
9 Cited Publications
Cat. No.: HY-138298
CAS No.: 1826843-81-5
Purity:  98.90%
Synonyms: T-DXd (solution); DS-8201 (solution); DS-8201a (solution)
Trastuzumab deruxtecan (T-DXd; DS-8201a) (solution) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). Trastuzumab deruxtecan is composed of a humanized anti-HER2 antibody, an enzymatically cleavable peptide-linker, a topoisomerase I inhibitor (a toxin component of Dxd), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E). Trastuzumab deruxtecan can be used for the research of HER2-positive breast cancer and gastric cancer .
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9
9 Cited Publications
Cat. No.: HY-138298A
CAS No.: 1826843-81-5
Purity:  99.58%
Synonyms: T-DXd; DS-8201; DS-8201a
Trastuzumab deruxtecan (DS-8201a) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). Trastuzumab deruxtecan is composed of a humanized anti-HER2 antibody, an enzymatically cleavable peptide-linker, a topoisomerase I inhibitor (a toxin component of Dxd), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E). Trastuzumab deruxtecan can be used for the research of HER2-positive breast cancer and gastric cancer .
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7
7 Cited Publications
Cat. No.: HY-P7224
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CXCL8; Lung Giant Cell Carcinoma-Derived Chemotactic Protein; Prev. IL8; Alveolar Macrophage Chemotactic factor I; MDNCF; Tumor Necrosis factor-Induced Gene 1; NAP-1; Neutrophil-Activating Peptide 1; MONAP; T-Cell Chemotactic factor; GCP-1; Interleukin 8; Monocyte-Derived Neutrophil Chemotactic factor; Interleukin-8; Monocyte-Derived Neutrophil-Activating Peptide; Emoctakin; Granulocyte Chemotactic Protein 1; AMCF-I; Chemokine (C-X-C Motif) Ligand 8; B-ENAP; SCYB8; TSG-1; LYNAP; 3-10C; LUCT; K60; LECT; Small Inducible Cytokine Subfamily B, Member 8; IL-8; Beta-Thromboglobulin-Like Protein; GCP1; Neutrophil-Activating Protein 1; NAP1; C-X-C Motif Chemokine 8; NAF; C-X-C Motif Chemokine; Beta Endothelial Cell-Derived Neutrophil Activating Peptide; Protein 3-10C; C-X-C Motif Chemokine Ligand 8; Lymphocyte Derived Neutrophil Activating Peptide
Species:  
Human
Source:  
E. coli
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6
6 Cited Publications
Cat. No.: HY-P70788
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGF1; Somatomedin-C; Insulin Like Growth factor 1; IGF1A; IGF-I; MGF; Insulin-Like Growth factor 1; Insulin-Like Growth factor IB; Insulin-Like Growth factor I; Insulin-Like Growth factor-I; IGFI; Alternative Protein IGF1; IGF; Somatomedin C; Insulin-Like
Species:  
Human
Source:  
E. coli
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5
5 Cited Publications
Cat. No.: HY-10199A
CAS No.: 159634-47-6
Purity:  98.52%
Synonyms: MK-677 free base; MK-0677 free base
Ibutamoren (MK-677 free base; MK-0677 free base) is an orally active non-peptide growth hormone secretagogue receptor agonist. Ibutamoren activates signal cascades by mimicking endogenous ligands, triggers pulsatile release of growth hormone from the pituitary gland, and increases serum levels of IGF-1 and insulin-like growth factor-binding protein 3. Ibutamoren not only increases the frequency of growth hormone pulses in male individuals, but also promotes elevated bone formation markers in female individuals with postmenopausal osteoporosis. The combination of Ibutamoren with Alendronate sodium hydrate (HY-11101) significantly increases bone mineral density at the femoral neck. However, Ibutamoren may cause mild, reversible adverse reactions such as increased appetite, fluid retention, and elevated fasting blood glucose. Ibutamoren has been widely used in studies related to idiopathic growth hormone deficiency, sarcopenia, Alzheimer's disease, and osteoporosis .
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5
5 Cited Publications
Cat. No.: HY-P0221
CAS No.: 137061-48-4
Synonyms: Pituitary Adenylate Cyclase Activating Polypeptide 38
PACAP (1-38), human, ovine, rat is a PAC1 receptor agonist. PACAP (1-38), human, ovine, rat binds to PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2 with IC50s of 4 nM, 2 nM, and 1 nM, respectively. PACAP (1-38), human, ovine, rat increases the α-secretase activity. PACAP (1-38), human, ovine, rat elevates cytosolic Ca 2+, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP (1-38), human, ovine, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP (1-38), human, ovine, rat can be used for neurotrophic and neuroprotective research .
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4
4 Cited Publications
Cat. No.: HY-112951
CAS No.: 2438721-44-7
Purity:  99.91%
Target:  

STING

Research Areas:  

Cancer

ChX710 could prime the type I interferon response to cytosolic DNA, which induces the ISRE promoter sequence, specific cellular Interferon-Stimulated Genes (ISGs), and the phosphorylation of Interferon Regulatory Factor (IRF) 3.
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4
4 Cited Publications
Cat. No.: HY-P70698
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGF1; Somatomedin-C; Insulin Like Growth factor 1; IGF1A; IGF-I; MGF; Insulin-Like Growth factor 1; Insulin-Like Growth factor IB; Insulin-Like Growth factor I; Insulin-Like Growth factor-I; IGFI; Alternative Protein IGF1; IGF; Somatomedin C; Insulin-Like
Species:  
Mouse
Source:  
E. coli
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4
4 Cited Publications
Cat. No.: HY-P70576
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL3; Colony-Stimulating factor, Multiple; Interleukin 3; P-Cell Stimulating factor; IL-3; P-Cell-Stimulating factor; Hematopoietic Growth factor; Mast-Cell Growth factor; MCGF; Mast Cell Growth factor; Multipotential Colony-Stimulating factor; MGC79398; I
Species:  
Human
Source:  
E. coli
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4
4 Cited Publications
Cat. No.: HY-P70569
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CXCL8; Lung Giant Cell Carcinoma-Derived Chemotactic Protein; Prev. IL8; Alveolar Macrophage Chemotactic factor I; MDNCF; Tumor Necrosis factor-Induced Gene 1; NAP-1; Neutrophil-Activating Peptide 1; MONAP; T-Cell Chemotactic factor; GCP-1; Interleukin 8
Species:  
Human
Source:  
HEK293
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3
3 Cited Publications
Cat. No.: HY-110135A
Purity:  99.42%
Target:  

IGF-1R

Research Areas:  

Neurological Disease

NBI-31772 hydrate is a potent inhibitor of interaction between insulin-like growth factor (IGF) and IGF-binding proteins (IGFBPs). NBI-31772 hydrate is also a nonpeptide ligand that releases bioactive IGF-I from the IGF-I/IGFBP-3 complex (Kis=1-24 nM for all six human subtypes). Anxiolytic and antidepressant-like effects .
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3
3 Cited Publications
Cat. No.: HY-P7203
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGF1; Somatomedin-C; Insulin Like Growth factor 1; IGF1A; IGF-I; MGF; Insulin-Like Growth factor 1; Insulin-Like Growth factor IB; Insulin-Like Growth factor I; Insulin-Like Growth factor-I; IGFI; Alternative Protein IGF1; IGF; Somatomedin C; Insulin-Like
Species:  
Rat
Source:  
E. coli
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3
3 Cited Publications
Cat. No.: HY-P70685
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL3; Colony-Stimulating factor, Multiple; Interleukin 3; P-Cell Stimulating factor; IL-3; P-Cell-Stimulating factor; Hematopoietic Growth factor; Mast-Cell Growth factor; MCGF; Mast Cell Growth factor; Multipotential Colony-Stimulating factor; MGC79398; I
Species:  
Mouse
Source:  
HEK293
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3
3 Cited Publications
Cat. No.: HY-P7379
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CXCL8; Lung Giant Cell Carcinoma-Derived Chemotactic Protein; Prev. IL8; Alveolar Macrophage Chemotactic factor I; MDNCF; Tumor Necrosis factor-Induced Gene 1; NAP-1; Neutrophil-Activating Peptide 1; MONAP; T-Cell Chemotactic factor; GCP-1; Interleukin 8
Species:  
Human
Source:  
CHO
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