N-Fmoc-N'-(azido-PEG4)-L-Lysine-PFP ester

Name: N-Fmoc-N'-(azido-PEG4)-L-Lysine-PFP ester
Brand: MedChemExpress
SKU: HY-140847
Rating: 4.5 (0 reviews)

Cat. No.: HY-140847 Pureza: 95.0%: Ficha de datos
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N-Fmoc-N'-(azido-PEG4)-L-Lysine-PFP ester is an alkyl/ether and PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-Fmoc-N'-(azido-PEG4)-L-Lysine-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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N-Fmoc-N'-(azido-PEG4)-L-Lysine-PFP ester Estructura química

No. CAS : 2749985-69-9

Tamaño	Stock	Cantidad
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
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500 mg	Obtener un presupuesto

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Based on 1 Customer Validation

Other Forms of N-Fmoc-N'-(azido-PEG4)-L-Lysine-PFP ester:

Fmoc-NH-Azide-PEG4-L-Lysine-PFP ester Obtener un presupuesto

Recomendaciones destacadas

•Related Small Molecules:

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Actividad biológica
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Descripciòn

N-Fmoc-N'-(azido-PEG4)-L-Lysine-PFP ester is an alkyl/ether and PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. N-Fmoc-N'-(azido-PEG4)-L-Lysine-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC₅₀ & Target

Alkyl/ether

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

807.76

Fòrmula

C₃₈H₄₂F₅N₅O₉

No. CAS

2749985-69-9

Appearance

Solid

Color

White to off-white

SMILES

FC(C(F)=C(C(F)=C1F)F)=C1OC([C@H](CCCCNC(CCOCCOCCOCCOCCN=[N+]=[N-])=O)NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureza y Documentación

Purity: 95.0%

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Ficha de datos (265 KB) SDS (252 KB)

COA (244 KB) HNMR (308 KB) MS (70 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]